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Open AccessArticle

Plasma Long Noncoding RNA LeXis is a Potential Diagnostic Marker for Non-Alcoholic Steatohepatitis

1
Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea
2
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 41944, Korea
3
Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea
4
Department of Pathology, Dongsan Medical Center, School of Medicine, Keimyung University, Daegu 42601, Korea
5
Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea
6
Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea
7
Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan 74392, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this study.
Life 2020, 10(10), 230; https://doi.org/10.3390/life10100230
Received: 6 August 2020 / Revised: 27 September 2020 / Accepted: 29 September 2020 / Published: 3 October 2020
(This article belongs to the Special Issue Fatty Liver Syndrome)
Non-invasive diagnostic markers are needed to ease the diagnosis of non-alcoholic steatohepatitis (NASH) among patients with non-alcoholic fatty liver disease (NAFLD). The long noncoding RNA (lncRNA) LeXis is related to cholesterol metabolism and hepatic steatosis in mice, and its batch genome conversion in humans is TCONS_00016452. Here, we aimed to evaluate the potential of lncRNA LeXis as a non-invasive diagnostic marker for NASH. We analyzed a total of 44 NAFLD patients whose diagnosis was confirmed by a pathologist through analysis of a percutaneous liver biopsy. The expression of LeXis in the plasma of NAFLD patients with and without NASH was compared using quantitative real-time polymerase chain reaction. The expression of plasma LeXis was significantly higher in patients with NASH than in those with NAFL (8.2 (5.0–14.9); 4.6 (4.0–6.6), p = 0.025). The area under the receiver operating characteristic curve was 0.743 (95% CI 0.590–0.895, p < 0.001), and a sensitivity of 54.3% and specificity of 100% could be achieved for NASH diagnosis. Low LeXis was independently associated with NASH diagnosis in patients with NAFLD (p = 0.0349, odds ratio = 22.19 (5% CI, 1.25–395.22)). Therefore, circulating lncRNA LeXis could be a potential non-invasive diagnostic biomarker for NASH. View Full-Text
Keywords: biomarker; liver fibrosis; long noncoding RNA LeXis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; untranslated RNA biomarker; liver fibrosis; long noncoding RNA LeXis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; untranslated RNA
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MDPI and ACS Style

Park, J.G.; Kim, G.; Jang, S.Y.; Lee, Y.R.; Lee, E.; Lee, H.W.; Han, M.-H.; Chun, J.M.; Han, Y.S.; Yoon, J.S.; Kang, M.K.; Kweon, Y.O.; Tak, W.Y.; Park, S.Y.; Hur, K. Plasma Long Noncoding RNA LeXis is a Potential Diagnostic Marker for Non-Alcoholic Steatohepatitis. Life 2020, 10, 230. https://doi.org/10.3390/life10100230

AMA Style

Park JG, Kim G, Jang SY, Lee YR, Lee E, Lee HW, Han M-H, Chun JM, Han YS, Yoon JS, Kang MK, Kweon YO, Tak WY, Park SY, Hur K. Plasma Long Noncoding RNA LeXis is a Potential Diagnostic Marker for Non-Alcoholic Steatohepatitis. Life. 2020; 10(10):230. https://doi.org/10.3390/life10100230

Chicago/Turabian Style

Park, Jung G.; Kim, Gyeonghwa; Jang, Se Y.; Lee, Yu R.; Lee, Eunhye; Lee, Hye W.; Han, Man-Hoon; Chun, Jae M.; Han, Young S.; Yoon, Jun S.; Kang, Min K.; Kweon, Young O.; Tak, Won Y.; Park, Soo Y.; Hur, Keun. 2020. "Plasma Long Noncoding RNA LeXis is a Potential Diagnostic Marker for Non-Alcoholic Steatohepatitis" Life 10, no. 10: 230. https://doi.org/10.3390/life10100230

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