Facile Preparation of Organo-Modified ZnO/Attapulgite Nanocomposites Loaded with Monoammonium Glycyrrhizinate via Mechanical Milling and Their Synergistic Antibacterial Effect

Yang, Fangfang; Song, Yameng; Hui, Aiping; Kang, Yuru; Zhou, Yanmin; Wang, Aiqin

doi:10.3390/min12030364

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Facile Preparation of Organo-Modified ZnO/Attapulgite Nanocomposites Loaded with Monoammonium Glycyrrhizinate via Mechanical Milling and Their Synergistic Antibacterial Effect

by

Fangfang Yang

¹,

Yameng Song

^1,2,

Aiping Hui

¹,

Yuru Kang

¹,

Yanmin Zhou

³ and

Aiqin Wang

^1,*

¹

Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-Material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730030, China

²

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

³

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China

^*

Author to whom correspondence should be addressed.

Minerals 2022, 12(3), 364; https://doi.org/10.3390/min12030364

Submission received: 20 February 2022 / Revised: 12 March 2022 / Accepted: 15 March 2022 / Published: 16 March 2022

(This article belongs to the Special Issue Nanotubular and Nanofibrous Clay Minerals)

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Abstract

In this study, monoammonium glycyrrhizinate (MAG) was introduced into cetyltrimethyl ammonium bromide (CTAB)-modified ZnO/attapulgite (APT) via a mechanical process to form performance-enhanced antibacterial nanocomposites (MAG/C–ZnO/APT). The APT supported ZnO nanocomposite (ZnO/APT) was prepared by a conventional precipitation method, and 20–50 nm of globular ZnO nanoparticles were uniformly decorated on APT nanorods. The FTIR and zeta potential analyses demonstrated that modification by CTAB facilitated the loading of MAG into ZnO/APT by H-bonding and electrostatic interactions. Antibacterial evaluation results indicate that MAG/C–ZnO/APT nanocomposites with CTAB and MAG doses of 2.5% and 0.25%, respectively, exhibited synergistically enhanced inhibitory activities against Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamases Escherichia coli, with minimum inhibitory concentrations of 1, 0.1, 0.25, 5, 0.1, and 2.5 mg/mL, respectively, which are better than those of ZnO/APT, C–ZnO/APT and MAG. Moreover, the nanocomposites had low cytotoxicity on human normal cell line L-O2. Therefore, this study provided a more effective strategy to extend the antibacterial spectrum and strengthen the inhibitory effects of antibiotic-free materials to address increasingly serious situations of microbial infection.

Keywords: Monoammonium glycyrrhizinate; CTAB; ZnO; Attapulgite; nanocomposite; antibacterial

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MDPI and ACS Style

Yang, F.; Song, Y.; Hui, A.; Kang, Y.; Zhou, Y.; Wang, A. Facile Preparation of Organo-Modified ZnO/Attapulgite Nanocomposites Loaded with Monoammonium Glycyrrhizinate via Mechanical Milling and Their Synergistic Antibacterial Effect. Minerals 2022, 12, 364. https://doi.org/10.3390/min12030364

AMA Style

Yang F, Song Y, Hui A, Kang Y, Zhou Y, Wang A. Facile Preparation of Organo-Modified ZnO/Attapulgite Nanocomposites Loaded with Monoammonium Glycyrrhizinate via Mechanical Milling and Their Synergistic Antibacterial Effect. Minerals. 2022; 12(3):364. https://doi.org/10.3390/min12030364

Chicago/Turabian Style

Yang, Fangfang, Yameng Song, Aiping Hui, Yuru Kang, Yanmin Zhou, and Aiqin Wang. 2022. "Facile Preparation of Organo-Modified ZnO/Attapulgite Nanocomposites Loaded with Monoammonium Glycyrrhizinate via Mechanical Milling and Their Synergistic Antibacterial Effect" Minerals 12, no. 3: 364. https://doi.org/10.3390/min12030364

APA Style

Yang, F., Song, Y., Hui, A., Kang, Y., Zhou, Y., & Wang, A. (2022). Facile Preparation of Organo-Modified ZnO/Attapulgite Nanocomposites Loaded with Monoammonium Glycyrrhizinate via Mechanical Milling and Their Synergistic Antibacterial Effect. Minerals, 12(3), 364. https://doi.org/10.3390/min12030364

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Facile Preparation of Organo-Modified ZnO/Attapulgite Nanocomposites Loaded with Monoammonium Glycyrrhizinate via Mechanical Milling and Their Synergistic Antibacterial Effect

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