Next Article in Journal
Topological and Thermodynamic Entropy Measures for COVID-19 Pandemic through Graph Theory
Next Article in Special Issue
Mechanistic Insights into Plant Chiral Growth
Previous Article in Journal
An Iterative Weighted-Mean Filter for Removal of High-Density Salt-and-Pepper Noise
Previous Article in Special Issue
Non-Random Sister Chromatid Segregation in Human Tissue Stem Cells
Article

Statistical Validation Verifies That Enantiomorphic States of Chiral Cells Are Determinant Dictating the Left- or Right-Handed Direction of the Hindgut Rotation in Drosophila

1
Graduate School of Agriculture, Kyoto University, Kyoto 569-0073, Japan
2
Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan
*
Author to whom correspondence should be addressed.
Symmetry 2020, 12(12), 1991; https://doi.org/10.3390/sym12121991
Received: 9 November 2020 / Revised: 25 November 2020 / Accepted: 30 November 2020 / Published: 2 December 2020
(This article belongs to the Special Issue Left-Right Asymmetry in Cell Biology)
In the left–right (LR) asymmetric development of invertebrates, cell chirality is crucial. A left- or right-handed cell structure directs morphogenesis with corresponding LR-asymmetry. In Drosophila, cell chirality is thought to drive the LR-asymmetric development of the embryonic hindgut and other organs. This hypothesis is supported only by an apparent concordance between the LR-directionality of cell chirality and hindgut rotation and by computer simulations that connect the two events. In this article, we mathematically evaluated the causal relationship between the chirality of the hindgut epithelial cells and the LR-direction of hindgut rotation. Our logistic model, drawn from several Drosophila genotypes, significantly explained the correlation between the enantiomorphic (sinistral or dextral) state of chiral cells and the LR-directionality of hindgut rotation—even in individual live mutant embryos with stochastically determined cell chirality and randomized hindgut rotation, suggesting that the mechanism by which cell chirality forms is irrelevant to the direction of hindgut rotation. Thus, our analysis showed that cell chirality, which forms before hindgut rotation, is both sufficient and required for the subsequent rotation, validating the hypothesis that cell chirality causally defines the LR-directionality of hindgut rotation. View Full-Text
Keywords: cell chirality; left–right asymmetry; gut; development; Drosophila cell chirality; left–right asymmetry; gut; development; Drosophila
Show Figures

Figure 1

MDPI and ACS Style

Ishibashi, T.; Inaki, M.; Matsuno, K. Statistical Validation Verifies That Enantiomorphic States of Chiral Cells Are Determinant Dictating the Left- or Right-Handed Direction of the Hindgut Rotation in Drosophila. Symmetry 2020, 12, 1991. https://doi.org/10.3390/sym12121991

AMA Style

Ishibashi T, Inaki M, Matsuno K. Statistical Validation Verifies That Enantiomorphic States of Chiral Cells Are Determinant Dictating the Left- or Right-Handed Direction of the Hindgut Rotation in Drosophila. Symmetry. 2020; 12(12):1991. https://doi.org/10.3390/sym12121991

Chicago/Turabian Style

Ishibashi, Tomoki, Mikiko Inaki, and Kenji Matsuno. 2020. "Statistical Validation Verifies That Enantiomorphic States of Chiral Cells Are Determinant Dictating the Left- or Right-Handed Direction of the Hindgut Rotation in Drosophila" Symmetry 12, no. 12: 1991. https://doi.org/10.3390/sym12121991

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop