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Open AccessArticle

Histological and Histomorphometric Analyses of Two Bovine Bone Blocks Implanted in Rabbit Calvaria

1
Research Department, Biotecnos–Technology and Science, Cuareim 1483, 11100-Montevideo, Uruguay
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Instituto de Bioingenieria, Universidad Miguel Hernandez, Avda. Ferrocarril s/n. 03202-Elche, (Alicante), Spain
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Departamento de Materiales, Óptica y Tecnologia Electrónica, Universidad Miguel Hernández, Avda. Universidad s/n, 03202-Elche (Alicante), Spain
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Department of Biomedical, Surgical and Dental Sciences, Università Degli Studi di Milano, via Commenda 10, 20122-Milan, Italy
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IRCCS Orthopedic Institute Galeazzi, via R. Galeazzi 4. 20161-Milan, Italy
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Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100-Chieti, Italy
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Department of Medicine Veterinary, Faculty of Itapiranga, Andradas s/n, 89896000-Itapiranga, Brazil
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Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la Republica, 11400-Montevideo, Uruguay
*
Author to whom correspondence should be addressed.
Symmetry 2019, 11(5), 641; https://doi.org/10.3390/sym11050641
Received: 12 February 2019 / Revised: 1 May 2019 / Accepted: 5 May 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Biomaterials and Symmetry)
This study compared the osteogenic potential of two types of bovine bone blocks. Blocks were obtained by either sintered or a nonsintered process. Calvaria were surgically exposed in 20 rabbits. In each animal, six 0.5-mm-diameter cortical microperforations were drilled with a carbide bur before grafting to promote graft irrigation. The sintered (group 1) and nonsintered (group 2) bovine bone blocks (6 mm diameter, 5 mm high) were bilaterally screwed onto calvarial bone. Blocks were previously prepared from a larger block using a trephine bur. Rabbits were sacrificed after 6 and 8 weeks for the histological and histomorphometric analyses. Samples were processed using the historesin technique. The quantitative and qualitative analyses of the newly formed bone were undertaken using light microscopy. Both groups showed modest new bone formation and remodeling. At the 8-week follow-up, the sintered group displayed significantly lower bone resorption (average of 10% in group 1 and 25% in group 2) and neo-formation (12.86 ± 1.52%) compared to the nonsintered group (16.10 ± 1.29%) at both follow-ups (p < 0.05). One limitation of the present animal model is that the study demonstrates that variations in the physico-chemical properties of the bone substitute material clearly influence the in vivo behavior. View Full-Text
Keywords: bovine bone block; sintered ceramic; nonsintered ceramic; animal study; rabbit calvaria; histomorphometric analysis bovine bone block; sintered ceramic; nonsintered ceramic; animal study; rabbit calvaria; histomorphometric analysis
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Gehrke, S.A.; Mazón, P.; Del Fabbro, M.; Tumedei, M.; Aramburú Júnior, J.; Pérez-Díaz, L.; De Aza, P.N. Histological and Histomorphometric Analyses of Two Bovine Bone Blocks Implanted in Rabbit Calvaria. Symmetry 2019, 11, 641.

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