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Symmetry 2018, 10(3), 73; https://doi.org/10.3390/sym10030073

Intelligent Image Processing System for Detection and Segmentation of Regions of Interest in Retinal Images

Department of Control Engineering and Industrial Informatics, University Politehnica of Bucharest, 060042 Bucharest, Romania
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Received: 12 February 2018 / Revised: 3 March 2018 / Accepted: 15 March 2018 / Published: 17 March 2018
(This article belongs to the Special Issue Advances in Medical Image Segmentation)
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Abstract

The automatic detection, segmentation, localization, and evaluation of the optic disc, macula, exudates, and hemorrhages are very important for diagnosing retinal diseases. One of the difficulties in detecting such regions of interest (RoIs) with computer vision is their symmetries, e.g., between the optic disc and exudates and also between exudates and hemorrhages. This paper proposes an original, intelligent, and high-performing image processing system for the simultaneous detection and segmentation of retinal RoIs. The basic principles of the method are image decomposition in small boxes and local texture analysis. The processing flow contains three phases: preprocessing, learning, and operating. As a first novelty, we propose proper feature selection based on statistical analysis in confusion matrices for different feature types (extracted from a co-occurrence matrix, fractal type, and local binary patterns). Mainly, the selected features are chosen to differentiate between similar RoIs. The second novelty consists of local classifier fusion. To this end, the local classifiers associated with features are grouped in global classifiers corresponding to the RoIs. The local classifiers are based on minimum distances to the representatives of classes and the global classifiers are based on confidence intervals, weights, and a voting scheme. A deep convolutional neural network, based on supervised learning, for blood vessel segmentation is proposed in order to improve the RoI detection performance. Finally, the experimental results on real images from different databases demonstrate the rightness of our methodologies and algorithms. View Full-Text
Keywords: biomedical image processing; retinal image segmentation; feature selection; texture analysis; convolutional neural network; optic disc; macula; exudates; hemorrhages biomedical image processing; retinal image segmentation; feature selection; texture analysis; convolutional neural network; optic disc; macula; exudates; hemorrhages
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Popescu, D.; Ichim, L. Intelligent Image Processing System for Detection and Segmentation of Regions of Interest in Retinal Images. Symmetry 2018, 10, 73.

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