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Genes 2018, 9(12), 600; https://doi.org/10.3390/genes9120600

The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation

School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China
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Received: 1 November 2018 / Revised: 27 November 2018 / Accepted: 29 November 2018 / Published: 3 December 2018
(This article belongs to the Special Issue Role of DNA Methyltransferases in the Epigenome)
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Abstract

Mammalian DNMT1 is mainly responsible for maintenance DNA methylation that is critical in maintaining stem cell pluripotency and controlling lineage specification during early embryonic development. A number of studies have demonstrated that DNMT1 is an auto-inhibited enzyme and its enzymatic activity is allosterically regulated by a number of interacting partners. UHRF1 has previously been reported to regulate DNMT1 in multiple ways, including control of substrate specificity and the proper genome targeting. In this review, we discuss the recent advances in our understanding of the regulation of DNMT1 enzymatic activity by UHRF1 and highlight a number of unresolved questions. View Full-Text
Keywords: DNA methylation; DNMT1; UHRF1; USP7; ubiquitination DNA methylation; DNMT1; UHRF1; USP7; ubiquitination
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Xie, S.; Qian, C. The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation. Genes 2018, 9, 600.

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