Next Article in Journal
Tissue Non-Specific Genes and Pathways Associated with Diabetes: An Expression Meta-Analysis
Next Article in Special Issue
Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis
Previous Article in Journal
Regulation of DNA Replication in Early Embryonic Cleavages
Previous Article in Special Issue
The Complex Relationship between Virulence and Antibiotic Resistance
Open AccessReview

Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review

Institute for Bioengineering and Biosciences (IBB), and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Helen J. Wing
Genes 2017, 8(1), 43; https://doi.org/10.3390/genes8010043
Received: 7 November 2016 / Revised: 11 January 2017 / Accepted: 12 January 2017 / Published: 19 January 2017
(This article belongs to the Special Issue Virulence Gene Regulation in Bacteria)
Burkholderia cepacia complex (Bcc) bacteria emerged as opportunistic pathogens in cystic fibrosis and immunocompromised patients. Their eradication is very difficult due to the high level of intrinsic resistance to clinically relevant antibiotics. Bcc bacteria have large and complex genomes, composed of two to four replicons, with variable numbers of insertion sequences. The complexity of Bcc genomes confers a high genomic plasticity to these bacteria, allowing their adaptation and survival to diverse habitats, including the human host. In this work, we review results from recent studies using omics approaches to elucidate in vivo adaptive strategies and virulence gene regulation expression of Bcc bacteria when infecting the human host or subject to conditions mimicking the stressful environment of the cystic fibrosis lung. View Full-Text
Keywords: Burkholderia cepacia complex (Bcc); cystic fibrosis (CF); post-genomic approaches; adaptive strategies Burkholderia cepacia complex (Bcc); cystic fibrosis (CF); post-genomic approaches; adaptive strategies
Show Figures

Figure 1

MDPI and ACS Style

Sousa, S.A.; Feliciano, J.R.; Pita, T.; Guerreiro, S.I.; Leitão, J.H. Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review. Genes 2017, 8, 43.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop