Regulation of DNA Replication in Early Embryonic Cleavages
AbstractEarly embryonic cleavages are characterized by short and highly synchronous cell cycles made of alternating S- and M-phases with virtually absent gap phases. In this contracted cell cycle, the duration of DNA synthesis can be extraordinarily short. Depending on the organism, the whole genome of an embryo is replicated at a speed that is between 20 to 60 times faster than that of a somatic cell. Because transcription in the early embryo is repressed, DNA synthesis relies on a large stockpile of maternally supplied proteins stored in the egg representing most, if not all, cellular genes. In addition, in early embryonic cell cycles, both replication and DNA damage checkpoints are inefficient. In this article, we will review current knowledge on how DNA synthesis is regulated in early embryos and discuss possible consequences of replicating chromosomes with little or no quality control. View Full-Text
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Kermi, C.; Lo Furno, E.; Maiorano, D. Regulation of DNA Replication in Early Embryonic Cleavages. Genes 2017, 8, 42.
Kermi C, Lo Furno E, Maiorano D. Regulation of DNA Replication in Early Embryonic Cleavages. Genes. 2017; 8(1):42.Chicago/Turabian Style
Kermi, Chames; Lo Furno, Elena; Maiorano, Domenico. 2017. "Regulation of DNA Replication in Early Embryonic Cleavages." Genes 8, no. 1: 42.
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