Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Ethical Statement
2.3. Biochemical Analyses
2.4. Genotyping
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Case (n = 334) (Myocardial Infarction) | Control (n = 737) (Without CAD) | p-Value | |
---|---|---|---|
Age (years) | 64.3 ± 9.8 | 64.1 ± 9.1 | 0.75 |
BMI (kg/m2) | 29.64 ± 4.14 | 30.69 ± 4.59 | <0.001 |
Waist circumference (cm) | 104.99 ± 11.42 | 107.86 ± 12.73 | 0.02 |
Male gender (%) | 200 (59.9) | 399 (54.1) | 0.09 |
Systolic blood pressure (mm Hg) | 148.1 ± 19.7 | 150.8 ± 19.7 | 0.06 |
Diastolic blood pressure (mm Hg) | 82.11 ± 10.59 | 84.63 ± 11.52 | <0.001 |
DM duration (years) | 15 (10–23) | 13 (10–18) | <0.001 |
Fasting plasma glucose (mmol/L) | 8.87 ± 2.90 | 8.60 ± 2.54 | 0.25 |
Smoking prevalence (%) | 43 (12.9) | 66 (9.0) | 0.05 |
Total cholesterol (mmol/L) | 5.15 ± 1.45 | 4.64 ± 1.12 | <0.001 |
HDL-c (mmol/L) | 1.14 ± 0.30 | 1.24 ± 0.35 | <0.001 |
LDL-c (mmol/L) | 2.94 (2.22–3.76) | 2.50 (2.02–3.10) | <0.001 |
Triglycerides (mmol/L) | 1.90 (1.34–2.70) | 1.60 (1.10–2.43) | <0.001 |
HbA1c (%) | 7.88 ± 1.34 | 7.50 ± 1.9 | 0.64 |
hsCRP (mg/L) | 2.40 (1.28–4.80) | 2.40 (1.30–3.90) | 0.15 |
CVI (%) | 27 (8.1) | 44 (6.0) | 0.20 |
TIA (%) | 17 (5.1) | 21 (2.8) | 0.07 |
Case (n = 334) | Control (n = 737) | p-Value | |
---|---|---|---|
CC (MAF *) | 96 (28.7%) | 164 (22.3%) | |
CG | 156 (46.7%) | 372 (50.5%) | 0.07 |
GG | 82 (24.6%) | 201 (27.3%) | |
C allele (%) | 348 (52.1%) | 700 (47.5%) | 0.05 |
G allele (%) | 320 (47.9%) | 774 (52.5%) | |
p-value (HWE) | 0.24 | 0.74 |
Genetic Model | Case/Control | AOR (95% CI) | p-Value |
---|---|---|---|
Co-dominant | |||
CC vs. GG * | 96/164 vs. 82/201 | 1.50 (1.02–2.21) | 0.04 |
CG vs. GG * | 156/372 vs. 82/201 | 1.14 (0.81–1.60) | 0.46 |
Dominant | |||
[CC + CG] vs. GG * | 252/536 vs. 82/201 | 1.06 (0.94–1.16) | 0.44 |
Recessive | |||
CC vs. [CG + GG] * | 96/164 vs. 238/573 | 1.38 (1.09–1.89) | 0.04 |
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Tibaut, M.; Naji, F.; Petrovič, D. Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus. Genes 2022, 13, 526. https://doi.org/10.3390/genes13030526
Tibaut M, Naji F, Petrovič D. Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus. Genes. 2022; 13(3):526. https://doi.org/10.3390/genes13030526
Chicago/Turabian StyleTibaut, Miha, Franjo Naji, and Daniel Petrovič. 2022. "Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus" Genes 13, no. 3: 526. https://doi.org/10.3390/genes13030526
APA StyleTibaut, M., Naji, F., & Petrovič, D. (2022). Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus. Genes, 13(3), 526. https://doi.org/10.3390/genes13030526