Next Article in Journal
Fine-Mapping of Sorghum Stay-Green QTL on Chromosome10 Revealed Genes Associated with Delayed Senescence
Next Article in Special Issue
Autosomal STR Profiling and Databanking in Malaysia: Current Status and Future Prospects
Previous Article in Journal
Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals
Previous Article in Special Issue
Challenges in Human Skin Microbial Profiling for Forensic Science: A Review
Open AccessArticle

A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups

by 1,2,3,†, 1,2,3,†, 4, 5, 1,2,3, 1,2,3, 1,2,3 and 1,2,5,*
1
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
2
College of Forensic Medicine, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
3
Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
4
Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an 710062, China
5
Multi-Omics Innovative Research Center of Forensic Identification, Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Genes 2020, 11(9), 1027; https://doi.org/10.3390/genes11091027
Received: 24 July 2020 / Revised: 19 August 2020 / Accepted: 28 August 2020 / Published: 1 September 2020
(This article belongs to the Special Issue Forensic Genetics and Genomics)
Novel genetic markers like microhaplotypes and compound markers show promising potential in forensic research. Based on previously reported single nucleotide polymorphism (SNP) and insertion/deletion (InDel) polymorphism loci, 29 genetic markers including 22 microhaplotypes and seven compound markers were identified. Genetic distributions of the 29 loci in five continental populations, Kazak and Mongolian groups in China were investigated. We found that the expected heterozygosity values of these 29 loci were >0.4 in these populations, indicating these loci were relatively high polymorphisms. Population genetic analyses of five continental populations showed that five loci displayed relatively high genetic variations among these continental populations and could be useful markers for ancestry analysis. In summary, the 29 loci displayed relatively high genetic diversities in continental populations and Chinese two groups and could be informative loci for forensic research. View Full-Text
Keywords: forensic research; microhaplotype; compound marker; Kazak; Mongolian forensic research; microhaplotype; compound marker; Kazak; Mongolian
Show Figures

Figure 1

MDPI and ACS Style

Jin, X.; Zhang, X.; Shen, C.; Liu, Y.; Cui, W.; Chen, C.; Guo, Y.; Zhu, B. A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups. Genes 2020, 11, 1027.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop