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Open AccessArticle

Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals

Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA
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Genes 2020, 11(9), 1025; https://doi.org/10.3390/genes11091025
Received: 17 June 2020 / Revised: 21 August 2020 / Accepted: 24 August 2020 / Published: 1 September 2020
(This article belongs to the Special Issue Genetics and Genomics of Zoonotic Foodborne Pathogens)
Salmonella is a leading cause of bacterial infections in animals and humans. We sequenced a collection of 450 Salmonella strains from diseased animals to better understand the genetic makeup of their virulence and resistance features. The presence of Salmonella pathogenicity islands (SPIs) varied by serotype. S. Enteritidis carried the most SPIs (n = 15), while S. Mbandaka, S. Cerro, S. Meleagridis, and S. Havana carried the least (n = 10). S. Typhimurium, S. Choleraesuis, S. I 4,5,12:i:-, and S. Enteritidis each contained the spv operon on IncFII or IncFII-IncFIB hybrid plasmids. Two S. IIIa carried a spv operon with spvD deletion on the chromosome. Twelve plasmid types including 24 hybrid plasmids were identified. IncA/C was frequently associated with S. Newport (83%) and S. Agona (100%) from bovine, whereas IncFII (100%), IncFIB (100%), and IncQ1 (94%) were seen in S. Choleraesuis from swine. IncX (100%) was detected in all S. Kentucky from chicken. A total of 60 antimicrobial resistance genes (ARGs), four disinfectant resistances genes (DRGs) and 33 heavy metal resistance genes (HMRGs) were identified. The Salmonella strains from sick animals contained various SPIs, resistance genes and plasmid types based on the serotype and source of the isolates. Such complicated genomic structures shed light on the strain characteristics contributing to the severity of disease and treatment failures in Salmonella infections, including those causing illnesses in animals. View Full-Text
Keywords: Salmonella; pathogenicity islands; antimicrobial resistance; MDR plasmid Salmonella; pathogenicity islands; antimicrobial resistance; MDR plasmid
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MDPI and ACS Style

Zhao, S.; Li, C.; Hsu, C.-H.; Tyson, G.H.; Strain, E.; Tate, H.; Tran, T.-T.; Abbott, J.; McDermott, P.F. Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals. Genes 2020, 11, 1025. https://doi.org/10.3390/genes11091025

AMA Style

Zhao S, Li C, Hsu C-H, Tyson GH, Strain E, Tate H, Tran T-T, Abbott J, McDermott PF. Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals. Genes. 2020; 11(9):1025. https://doi.org/10.3390/genes11091025

Chicago/Turabian Style

Zhao, Shaohua; Li, Cong; Hsu, Chih-Hao; Tyson, Gregory H.; Strain, Errol; Tate, Heather; Tran, Thu-Thuy; Abbott, Jason; McDermott, Patrick F. 2020. "Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals" Genes 11, no. 9: 1025. https://doi.org/10.3390/genes11091025

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