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Article

Atypical Genotypes for Canine Agouti Signaling Protein Suggest Novel Chromosomal Rearrangement

1
Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA
2
Wisdom Health, FI-00290 Helsinki, Finland
3
Coronado, Sturgeon County, AB T0A 1N4, Canada
4
Wisdom Health, Vancouver, WA 98683, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(7), 739; https://doi.org/10.3390/genes11070739
Received: 16 April 2020 / Revised: 19 June 2020 / Accepted: 24 June 2020 / Published: 3 July 2020
(This article belongs to the Special Issue Coat Color Genetics)
Canine coat color is a readily observed phenotype of great interest to dog enthusiasts; it is also an excellent avenue to explore the mechanisms of genetics and inheritance. As such, multiple commercial testing laboratories include basic color alleles in their popular screening panels, allowing for the creation of genotyped datasets at a scale not before appreciated in canine genetic research. These vast datasets have revealed rare genotype anomalies that encourage further exploration of color and pattern inheritance. We previously reported the simultaneous presence of greater than two allele variants at the Agouti Signaling Protein (ASIP) locus in a commercial genotype cohort of 11,790 canids. Here we present additional data to characterize the occurrence of anomalous ASIP genotypes. We document the detection of combinations of three or four ASIP allele variants in 17 dog breeds and Dingoes, at within-breed frequencies of 1.32–63.34%. We analyze the potential impact on phenotype that these allele combinations present, and propose mechanisms that could account for the findings, including: gene recombination, duplication, and incorrect causal variant identification. These findings speak to the accuracy of industry-wide protocols for commercial ASIP genotyping and imply that ASIP should be analyzed via haplotype, rather than using only the existing allele hierarchy, in the future. View Full-Text
Keywords: dog; coat color; colour; ASIP; duplication; gene; recombination; allele dog; coat color; colour; ASIP; duplication; gene; recombination; allele
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MDPI and ACS Style

Dreger, D.L.; Anderson, H.; Donner, J.; Clark, J.A.; Dykstra, A.; Hughes, A.M.; Ekenstedt, K.J. Atypical Genotypes for Canine Agouti Signaling Protein Suggest Novel Chromosomal Rearrangement. Genes 2020, 11, 739. https://doi.org/10.3390/genes11070739

AMA Style

Dreger DL, Anderson H, Donner J, Clark JA, Dykstra A, Hughes AM, Ekenstedt KJ. Atypical Genotypes for Canine Agouti Signaling Protein Suggest Novel Chromosomal Rearrangement. Genes. 2020; 11(7):739. https://doi.org/10.3390/genes11070739

Chicago/Turabian Style

Dreger, Dayna L., Heidi Anderson, Jonas Donner, Jessica A. Clark, Arlene Dykstra, Angela M. Hughes, and Kari J. Ekenstedt. 2020. "Atypical Genotypes for Canine Agouti Signaling Protein Suggest Novel Chromosomal Rearrangement" Genes 11, no. 7: 739. https://doi.org/10.3390/genes11070739

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