Next Article in Journal
A Third MLPH Variant Causing Coat Color Dilution in Dogs
Previous Article in Journal
Novel Brown Coat Color (Cocoa) in French Bulldogs Results from a Nonsense Variant in HPS3
Previous Article in Special Issue
Genomic Instability in Fungal Plant Pathogens
Open AccessReview

Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi

Department of Biochemistry and Biophysics, Oregon State University, Corvallis OR 97331, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Genes 2020, 11(6), 638; https://doi.org/10.3390/genes11060638
Received: 4 May 2020 / Revised: 27 May 2020 / Accepted: 4 June 2020 / Published: 9 June 2020
(This article belongs to the Special Issue Genome Plasticity of Human and Plant Pathogenic Fungi)
Genome integrity is essential to maintain cellular function and viability. Consequently, genome instability is frequently associated with dysfunction in cells and associated with plant, animal, and human diseases. One consequence of relaxed genome maintenance that may be less appreciated is an increased potential for rapid adaptation to changing environments in all organisms. Here, we discuss evidence for the control and function of facultative heterochromatin, which is delineated by methylation of histone H3 lysine 27 (H3K27me) in many fungi. Aside from its relatively well understood role in transcriptional repression, accumulating evidence suggests that H3K27 methylation has an important role in controlling the balance between maintenance and generation of novelty in fungal genomes. We present a working model for a minimal repressive network mediated by H3K27 methylation in fungi and outline challenges for future research. View Full-Text
Keywords: Cryptococcus; fungi; Fusarium; histones; lysine methylation; Neurospora; polycomb repressive complex; PRC2; Zymoseptoria Cryptococcus; fungi; Fusarium; histones; lysine methylation; Neurospora; polycomb repressive complex; PRC2; Zymoseptoria
Show Figures

Figure 1

MDPI and ACS Style

Ridenour, J.B.; Möller, M.; Freitag, M. Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi. Genes 2020, 11, 638.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop