Next Article in Journal
Cytogenetic Characterization of Seven Novel satDNA Markers in Two Species of Spined Loaches (Cobitis) and Their Clonal Hybrids
Next Article in Special Issue
Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
Previous Article in Journal
Could the Heat Shock Proteins 70 Family Members Exacerbate the Immune Response in Multiple Sclerosis? An in Silico Study
Previous Article in Special Issue
A Novel Germline MLH1 In-Frame Deletion in a Slovenian Lynch Syndrome Family Associated with Uncommon Isolated PMS2 Loss in Tumor Tissue
Perspective

G9a Is SETting the Stage for Colorectal Oncogenesis

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada
*
Author to whom correspondence should be addressed.
Genes 2020, 11(6), 616; https://doi.org/10.3390/genes11060616
Received: 28 April 2020 / Revised: 31 May 2020 / Accepted: 2 June 2020 / Published: 4 June 2020
(This article belongs to the Special Issue Colorectal Cancer Genetics, Epigenetics, and Emerging Therapies)
Recently, Kato et al. reported recurrent activating mutations in the SET domain of histone methyltransferase G9a, driving an oncogenic cascade in melanoma. The authors also reported correlations between G9a expression and the regulation of the canonical WNT pathway. Although we could not observe such mutations in human colorectal adenocarcinoma, newly reported findings are of high relevance to colorectal cancer, as WNT target gene signatures were closely associated with G9a expression. Here, we put into perspective such new results on G9a expression in colorectal cancers and the potential relationship with tumor heterogeneity and acquisition of neoplastic stemness. View Full-Text
Keywords: colorectal cancer; epigenetics; G9a; driving mutations; cancer stem cells colorectal cancer; epigenetics; G9a; driving mutations; cancer stem cells
Show Figures

Figure 1

MDPI and ACS Style

Bergin, C.J.; Benoit, Y.D. G9a Is SETting the Stage for Colorectal Oncogenesis. Genes 2020, 11, 616. https://doi.org/10.3390/genes11060616

AMA Style

Bergin CJ, Benoit YD. G9a Is SETting the Stage for Colorectal Oncogenesis. Genes. 2020; 11(6):616. https://doi.org/10.3390/genes11060616

Chicago/Turabian Style

Bergin, Christopher J., and Yannick D. Benoit 2020. "G9a Is SETting the Stage for Colorectal Oncogenesis" Genes 11, no. 6: 616. https://doi.org/10.3390/genes11060616

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop