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G9a Is SETting the Stage for Colorectal Oncogenesis

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada
Author to whom correspondence should be addressed.
Genes 2020, 11(6), 616;
Received: 28 April 2020 / Revised: 31 May 2020 / Accepted: 2 June 2020 / Published: 4 June 2020
(This article belongs to the Special Issue Colorectal Cancer Genetics, Epigenetics, and Emerging Therapies)
Recently, Kato et al. reported recurrent activating mutations in the SET domain of histone methyltransferase G9a, driving an oncogenic cascade in melanoma. The authors also reported correlations between G9a expression and the regulation of the canonical WNT pathway. Although we could not observe such mutations in human colorectal adenocarcinoma, newly reported findings are of high relevance to colorectal cancer, as WNT target gene signatures were closely associated with G9a expression. Here, we put into perspective such new results on G9a expression in colorectal cancers and the potential relationship with tumor heterogeneity and acquisition of neoplastic stemness. View Full-Text
Keywords: colorectal cancer; epigenetics; G9a; driving mutations; cancer stem cells colorectal cancer; epigenetics; G9a; driving mutations; cancer stem cells
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MDPI and ACS Style

Bergin, C.J.; Benoit, Y.D. G9a Is SETting the Stage for Colorectal Oncogenesis. Genes 2020, 11, 616.

AMA Style

Bergin CJ, Benoit YD. G9a Is SETting the Stage for Colorectal Oncogenesis. Genes. 2020; 11(6):616.

Chicago/Turabian Style

Bergin, Christopher J., and Yannick D. Benoit 2020. "G9a Is SETting the Stage for Colorectal Oncogenesis" Genes 11, no. 6: 616.

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