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Volume 11
Issue 7
10.3390/genes11070808
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Commentary

Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer

by
Aïcha Zouggar
†,
Joshua R. Haebe
† and
Yannick D. Benoit
*
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada
*
Author to whom correspondence should be addressed.
†
Equal contribution.
Genes 2020, 11(7), 808; https://doi.org/10.3390/genes11070808
Submission received: 14 June 2020 / Revised: 11 July 2020 / Accepted: 15 July 2020 / Published: 16 July 2020
(This article belongs to the Special Issue Colorectal Cancer Genetics, Epigenetics, and Emerging Therapies)
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Abstract

In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic elements regulating genes associated with inflammatory response and colorectal cancer. Here, we discuss the impact of such a discovery on the understanding of how the intestinal microbiota may contribute to epigenetic reprogramming and influence the onset of colorectal tumorigenesis. Finally, we examine the prospect of TET inhibition strategies as a therapeutic and/or preventive approach for colorectal cancer in patients afflicted by inflammatory bowel disease.
Keywords: colorectal cancer; epigenetics; microbiota; DNA methylation; TET3; LINE1 colorectal cancer; epigenetics; microbiota; DNA methylation; TET3; LINE1

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MDPI and ACS Style

Zouggar, A.; Haebe, J.R.; Benoit, Y.D. Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer. Genes 2020, 11, 808. https://doi.org/10.3390/genes11070808

AMA Style

Zouggar A, Haebe JR, Benoit YD. Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer. Genes. 2020; 11(7):808. https://doi.org/10.3390/genes11070808

Chicago/Turabian Style

Zouggar, Aïcha, Joshua R. Haebe, and Yannick D. Benoit. 2020. "Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer" Genes 11, no. 7: 808. https://doi.org/10.3390/genes11070808

APA Style

Zouggar, A., Haebe, J. R., & Benoit, Y. D. (2020). Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer. Genes, 11(7), 808. https://doi.org/10.3390/genes11070808

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