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Cas3 Protein—A Review of a Multi-Tasking Machine

1
School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK
2
Department of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia
*
Authors to whom correspondence should be addressed.
Genes 2020, 11(2), 208; https://doi.org/10.3390/genes11020208
Received: 13 January 2020 / Revised: 14 February 2020 / Accepted: 16 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue CRISPR-Cas: Interactions with Genome and Physiological Maintenance)
Cas3 has essential functions in CRISPR immunity but its other activities and roles, in vitro and in cells, are less widely known. We offer a concise review of the latest understanding and questions arising from studies of Cas3 mechanism during CRISPR immunity, and highlight recent attempts at using Cas3 for genetic editing. We then spotlight involvement of Cas3 in other aspects of cell biology, for which understanding is lacking—these focus on CRISPR systems as regulators of cellular processes in addition to defense against mobile genetic elements. View Full-Text
Keywords: CRISPR; Cas3; helicase; nuclease; biofilm CRISPR; Cas3; helicase; nuclease; biofilm
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He, L.; St. John James, M.; Radovcic, M.; Ivancic-Bace, I.; Bolt, E.L. Cas3 Protein—A Review of a Multi-Tasking Machine. Genes 2020, 11, 208.

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