Next Article in Journal
Evolution of the Small Family of Alternative Splicing Modulators Nuclear Speckle RNA-Binding Proteins in Plants
Next Article in Special Issue
A Gold Standard, CRISPR/Cas9-Based Complementation Strategy Reliant on 24 Nucleotide Bookmark Sequences
Previous Article in Journal
Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases
Previous Article in Special Issue
Genome Maintenance Proteins Modulate Autoimmunity Mediated Primed Adaptation by the Escherichia coli Type I-E CRISPR-Cas System

Cas3 Protein—A Review of a Multi-Tasking Machine

School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK
Department of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia
Authors to whom correspondence should be addressed.
Genes 2020, 11(2), 208;
Received: 13 January 2020 / Revised: 14 February 2020 / Accepted: 16 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue CRISPR-Cas: Interactions with Genome and Physiological Maintenance)
Cas3 has essential functions in CRISPR immunity but its other activities and roles, in vitro and in cells, are less widely known. We offer a concise review of the latest understanding and questions arising from studies of Cas3 mechanism during CRISPR immunity, and highlight recent attempts at using Cas3 for genetic editing. We then spotlight involvement of Cas3 in other aspects of cell biology, for which understanding is lacking—these focus on CRISPR systems as regulators of cellular processes in addition to defense against mobile genetic elements. View Full-Text
Keywords: CRISPR; Cas3; helicase; nuclease; biofilm CRISPR; Cas3; helicase; nuclease; biofilm
Show Figures

Figure 1

MDPI and ACS Style

He, L.; St. John James, M.; Radovcic, M.; Ivancic-Bace, I.; Bolt, E.L. Cas3 Protein—A Review of a Multi-Tasking Machine. Genes 2020, 11, 208.

AMA Style

He L, St. John James M, Radovcic M, Ivancic-Bace I, Bolt EL. Cas3 Protein—A Review of a Multi-Tasking Machine. Genes. 2020; 11(2):208.

Chicago/Turabian Style

He, Liu, Michael St. John James, Marin Radovcic, Ivana Ivancic-Bace, and Edward L. Bolt. 2020. "Cas3 Protein—A Review of a Multi-Tasking Machine" Genes 11, no. 2: 208.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop