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Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases

1
Department of Cell Biology, Microbiology and Molecular Biology, University of South, Florida, Tampa, FL 33620, USA
2
Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research, Institute, Tampa, FL 33612, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(2), 205; https://doi.org/10.3390/genes11020205
Received: 20 January 2020 / Revised: 11 February 2020 / Accepted: 14 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue DNA Helicases: Mechanisms, Biological Pathways, and Disease Relevance)
With roles in DNA repair, recombination, replication and transcription, members of the RecQ DNA helicase family maintain genome integrity from bacteria to mammals. Mutations in human RecQ helicases BLM, WRN and RecQL4 cause incurable disorders characterized by genome instability, increased cancer predisposition and premature adult-onset aging. Yeast cells lacking the RecQ helicase Sgs1 share many of the cellular defects of human cells lacking BLM, including hypersensitivity to DNA damaging agents and replication stress, shortened lifespan, genome instability and mitotic hyper-recombination, making them invaluable model systems for elucidating eukaryotic RecQ helicase function. Yeast and human RecQ helicases have common DNA substrates and domain structures and share similar physical interaction partners. Here, we review the major cellular functions of the yeast RecQ helicases Sgs1 of Saccharomyces cerevisiae and Rqh1 of Schizosaccharomyces pombe and provide an outlook on some of the outstanding questions in the field. View Full-Text
Keywords: RecQ helicases; Sgs1; Rqh1; yeast; genome instability RecQ helicases; Sgs1; Rqh1; yeast; genome instability
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MDPI and ACS Style

Gupta, S.V.; Schmidt, K.H. Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases. Genes 2020, 11, 205. https://doi.org/10.3390/genes11020205

AMA Style

Gupta SV, Schmidt KH. Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases. Genes. 2020; 11(2):205. https://doi.org/10.3390/genes11020205

Chicago/Turabian Style

Gupta, Sonia V.; Schmidt, Kristina H. 2020. "Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases" Genes 11, no. 2: 205. https://doi.org/10.3390/genes11020205

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