The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations

Piko, Peter; Fiatal, Szilvia; Werissa, Nardos Abebe; Bekele, Bayu Begashaw; Racz, Gabor; Kosa, Zsigmond; Sandor, Janos; Adany, Roza

doi:10.3390/genes11010056

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The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations

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MTA-DE Public Health Research Group, Public Health Research Institute, University of Debrecen, 4028 Debrecen, Hungary

Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, 4028 Debrecen, Hungary

WHO Collaborating Centre on Vulnerability and Health, University of Debrecen, 4028 Debrecen, Hungary

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Doctorial School of Health Sciences, University of Debrecen, Debrecen 4028, Hungary

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Department of Health Visitor Methodology and Public Health, Faculty of Health, University of Debrecen, 4400 Nyíregyháza, Hungary

Author to whom correspondence should be addressed.

Genes 2020, 11(1), 56; https://doi.org/10.3390/genes11010056

Received: 18 November 2019 / Revised: 30 December 2019 / Accepted: 31 December 2019 / Published: 3 January 2020

(This article belongs to the Section Human Genomics and Genetic Diseases)

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Abstract

Background: The triglycerides (TG) to high-density lipoprotein (HDL)-cholesterol (HDL-C) ratio (TG/HDL-C) is a well-known predictor for cardiovascular diseases (CVDs) with great heritability background. The cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) gene affect TG/HDL-C ratio. This study aims to explore the association between haplotypes (H) in CETP (based on 5 single nucleotide polymorphisms (SNPs)) and LIPC (based on 6 SNPs) genes and the TG/HDL-C ratio and its components, among Roma and Hungarian general populations. Methods: The prevalence of haplotypes and their effect on HDL-C, TG and TG/HDL-C ratio were calculated in both populations and compared. Results: Ten haplotypes in CETP and 6 in LIPC gene were identified. Three haplotypes in CETP and 3 in LIPC have significant effect on HDL-C level, whereas two in CETP and 3 in LIPC on TG level. The H6 in CETP (β = 0.52, p = 0.015; odds ratio (OR) = 1.87, p = 0.009) and H5 in LIPC (β = 0.56, p < 0.001; OR = 1.51, p = 0.002) have a significant increasing effect on TG/HDL-C ratio and have shown higher prevalence among the Roma, as compared to Hungarian general population. The H2 in the CETP gene has a decreasing effect on the TG/HDL-C ratio (OR = 0.58, p = 0.019) and is significantly less frequent among the Roma. Conclusions: Accumulation of harmful haplotypes in CETP and LIPC genes might have a role in the elevated TG/HDL-C ratio in the Roma population, which contributes to a higher risk in the development of cardiovascular diseases. View Full-Text

Keywords: single nucleotide polymorphism; triglyceride; high-density lipoprotein cholesterol; TG/HDL-C ratio; Roma; Hungarian general; CETP; LIPC; haplotype; cardiometabolic risk

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Piko, P.; Fiatal, S.; Werissa, N.A.; Bekele, B.B.; Racz, G.; Kosa, Z.; Sandor, J.; Adany, R. The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations. Genes 2020, 11, 56. https://doi.org/10.3390/genes11010056

AMA Style

Piko P, Fiatal S, Werissa NA, Bekele BB, Racz G, Kosa Z, Sandor J, Adany R. The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations. Genes. 2020; 11(1):56. https://doi.org/10.3390/genes11010056

Chicago/Turabian Style

Piko, Peter, Szilvia Fiatal, Nardos Abebe Werissa, Bayu Begashaw Bekele, Gabor Racz, Zsigmond Kosa, Janos Sandor, and Roza Adany. 2020. "The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations" Genes 11, no. 1: 56. https://doi.org/10.3390/genes11010056

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The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations

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