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Genetical Genomics of Tonic Immobility in the Chicken

AVIAN Behavioural Genomics and Physiology Group, IFM Biology, Linköping University, 58183 Linköping, Sweden
The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, Scotland EH25 9RG, UK
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, 750 07 Uppsala, Sweden
Author to whom correspondence should be addressed.
Genes 2019, 10(5), 341;
Received: 24 January 2019 / Revised: 17 April 2019 / Accepted: 30 April 2019 / Published: 7 May 2019
Identifying the molecular mechanisms of animal behaviour is an enduring goal for researchers. Gaining insight into these mechanisms enables us to gain a greater understanding of behaviour and their genetic control. In this paper, we perform Quantitative Trait Loci (QTL) mapping of tonic immobility behaviour in an advanced intercross line between wild and domestic chickens. Genes located within the QTL interval were further investigated using global expression QTL (eQTL) mapping from hypothalamus tissue, as well as causality analysis. This identified five candidate genes, with the genes PRDX4 and ACOT9 emerging as the best supported candidates. In addition, we also investigated the connection between tonic immobility, meat pH and struggling behaviour, as the two candidate genes PRDX4 and ACOT9 have previously been implicated in controlling muscle pH at slaughter. We did not find any phenotypic correlations between tonic immobility, struggling behaviour and muscle pH in a smaller additional cohort, despite these behaviours being repeatable within-test. View Full-Text
Keywords: QTL; eQTL; tonic immobility; behaviour; domestication; muscle pH QTL; eQTL; tonic immobility; behaviour; domestication; muscle pH
MDPI and ACS Style

Fogelholm, J.; Inkabi, S.; Höglund, A.; Abbey-Lee, R.; Johnsson, M.; Jensen, P.; Henriksen, R.; Wright, D. Genetical Genomics of Tonic Immobility in the Chicken. Genes 2019, 10, 341.

AMA Style

Fogelholm J, Inkabi S, Höglund A, Abbey-Lee R, Johnsson M, Jensen P, Henriksen R, Wright D. Genetical Genomics of Tonic Immobility in the Chicken. Genes. 2019; 10(5):341.

Chicago/Turabian Style

Fogelholm, Jesper, Samuel Inkabi, Andrey Höglund, Robin Abbey-Lee, Martin Johnsson, Per Jensen, Rie Henriksen, and Dominic Wright. 2019. "Genetical Genomics of Tonic Immobility in the Chicken" Genes 10, no. 5: 341.

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