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Tracking Biodistribution of Myeloid-Derived Cells in Murine Models of Breast Cancer

Department of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA
Xiangya School of Medicine, Central South University, 410008 Changsha, Hunan, China
Department of Pathology and Genomic Medicine, Houston, TX 77030, USA
Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Cancer Center, Houston Methodist Hospital, Houston, TX 77030, USA
Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 10065, USA
Author to whom correspondence should be addressed.
Current address: Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, 518036 Shenzhen, Guangdong, China.
Genes 2019, 10(4), 297;
Received: 21 February 2019 / Revised: 29 March 2019 / Accepted: 3 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue DNA Origami and Aptamer Assemblies)
PDF [1760 KB, uploaded 12 April 2019]


A growing tumor is constantly secreting inflammatory chemokines and cytokines that induce release of immature myeloid cells, including myeloid-derived suppressor cells (MDSCs) and macrophages, from the bone marrow. These cells not only promote tumor growth, but also prepare distant organs for tumor metastasis. On the other hand, the myeloid-derived cells also have phagocytic potential, and can serve as vehicles for drug delivery. We have previously identified thioaptamers that bind a subset of MDSCs with high affinity and specificity. In the current study, we applied one of the thioaptamers as a probe to track myeloid cell distribution in the bone, liver, spleen and tumor in multiple murine models of breast cancer including the 4T1 syngeneic model and MDA-MB-231 and SUM159 xenograft models. Information generated from this study will facilitate further understanding of tumor growth and metastasis, and predict biodistribution patterns of cell-mediated drug delivery. View Full-Text
Keywords: breast cancer; myeloid-derived suppressor cell; biodistribution; thioaptamer breast cancer; myeloid-derived suppressor cell; biodistribution; thioaptamer

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Li, J.; Mai, J.; Hinkle, L.; Lin, D.; Zhang, J.; Liu, X.; Ramirez, M.R.; Zu, Y.; Lokesh, G.L.; Volk, D.E.; Shen, H. Tracking Biodistribution of Myeloid-Derived Cells in Murine Models of Breast Cancer. Genes 2019, 10, 297.

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