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The Fusion of Lipid and DNA Nanotechnology

1
School of Biotechnology and Biomolecular Science, UNSW Sydney, KST 2052, Australia
2
School of Chemistry, University of Sydney, Camperdown 2006, Australia
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School of Chemical and Biomolecular Engineering, University of Sydney, Camperdown 2006, Australia
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Sydney Nanoscience Institute, University of Sydney, Camperdown 2006, Australia
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School of Physics, University of Sydney, Camperdown 2006, Australia
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CSIRO Synthetic Biology Future Science Platform, GPO Box 2583, Brisbane, QLD 4001, Australia
*
Authors to whom correspondence should be addressed.
Genes 2019, 10(12), 1001; https://doi.org/10.3390/genes10121001
Received: 28 October 2019 / Revised: 18 November 2019 / Accepted: 26 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue DNA Origami and Aptamer Assemblies)
Lipid membranes form the boundary of many biological compartments, including organelles and cells. Consisting of two leaflets of amphipathic molecules, the bilayer membrane forms an impermeable barrier to ions and small molecules. Controlled transport of molecules across lipid membranes is a fundamental biological process that is facilitated by a diverse range of membrane proteins, including ion-channels and pores. However, biological membranes and their associated proteins are challenging to experimentally characterize. These challenges have motivated recent advances in nanotechnology towards building and manipulating synthetic lipid systems. Liposomes—aqueous droplets enclosed by a bilayer membrane—can be synthesised in vitro and used as a synthetic model for the cell membrane. In DNA nanotechnology, DNA is used as programmable building material for self-assembling biocompatible nanostructures. DNA nanostructures can be functionalised with hydrophobic chemical modifications, which bind to or bridge lipid membranes. Here, we review approaches that combine techniques from lipid and DNA nanotechnology to engineer the topography, permeability, and surface interactions of membranes, and to direct the fusion and formation of liposomes. These approaches have been used to study the properties of membrane proteins, to build biosensors, and as a pathway towards assembling synthetic multicellular systems.
Keywords: lipid nanotechnology; DNA nanotechnology; DNA origami lipid nanotechnology; DNA nanotechnology; DNA origami
MDPI and ACS Style

Darley, E.; Singh, J.K.D.; Surace, N.A.; Wickham, S.F.J.; Baker, M.A.B. The Fusion of Lipid and DNA Nanotechnology. Genes 2019, 10, 1001.

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