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Open AccessArticle

Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity

1
Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy
2
MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Genes 2019, 10(2), 125; https://doi.org/10.3390/genes10020125
Received: 21 January 2019 / Revised: 4 February 2019 / Accepted: 4 February 2019 / Published: 8 February 2019
(This article belongs to the Special Issue Genetic Determinants of Human Longevity)
Biogerontological research highlighted a complex and dynamic connection between aging, health and longevity, partially determined by genetic factors. Multifunctional proteins with moonlighting features, by integrating different cellular activities in the space and time, may explain part of this complexity. Inositol Polyphosphate Multikinase (IPMK) is a potential moonlighting protein performing multiple unrelated functions. Initially identified as a key enzyme for inositol phosphates synthesis, small messengers regulating many aspects of cell physiology, IPMK is now implicated in a number of metabolic pathways affecting the aging process. IPMK regulates basic transcription, telomere homeostasis, nutrient-sensing, metabolism and oxidative stress. Here, we tested the hypothesis that the genetic variability of IPMK may affect human longevity. Single-SNP (single nuclear polymorphism), haplotype-based association tests as well as survival analysis pointed to the relevance of six out of fourteen genotyped SNPs for female longevity. In particular, haplotype analysis refined the association highlighting two SNPs, rs2790234 and rs6481383, as major contributing variants for longevity in women. Our work, the first to investigate the association between variants of IPMK and longevity, supports IPMK as a novel gender-specific genetic determinant of human longevity, playing a role in the complex network of genetic factors involved in human survival. View Full-Text
Keywords: aging; longevity; survival; SNP; polymorphism; IPMK; inositol phosphates; gender-specific association; moonlighting protein aging; longevity; survival; SNP; polymorphism; IPMK; inositol phosphates; gender-specific association; moonlighting protein
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MDPI and ACS Style

De Rango, F.; Crocco, P.; Iannone, F.; Saiardi, A.; Passarino, G.; Dato, S.; Rose, G. Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity. Genes 2019, 10, 125.

AMA Style

De Rango F, Crocco P, Iannone F, Saiardi A, Passarino G, Dato S, Rose G. Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity. Genes. 2019; 10(2):125.

Chicago/Turabian Style

De Rango, Francesco; Crocco, Paolina; Iannone, Francesca; Saiardi, Adolfo; Passarino, Giuseppe; Dato, Serena; Rose, Giuseppina. 2019. "Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity" Genes 10, no. 2: 125.

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