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The Mechanisms of Mating in Pathogenic Fungi—A Plastic Trait
Open AccessReview

Chromatin-Mediated Regulation of Genome Plasticity in Human Fungal Pathogens

Kent Fungal Group, School of Biosciences, University of Kent, Canterbury Kent CT2 7NJ, UK
Genes 2019, 10(11), 855; https://doi.org/10.3390/genes10110855
Received: 30 September 2019 / Revised: 18 October 2019 / Accepted: 25 October 2019 / Published: 28 October 2019
(This article belongs to the Special Issue Genome plasticity of human and plant pathogenic fungi)
Human fungal pathogens, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, are a public health problem, causing millions of infections and killing almost half a million people annually. The ability of these pathogens to colonise almost every organ in the human body and cause life-threating infections relies on their capacity to adapt and thrive in diverse hostile host-niche environments. Stress-induced genome instability is a key adaptive strategy used by human fungal pathogens as it increases genetic diversity, thereby allowing selection of genotype(s) better adapted to a new environment. Heterochromatin represses gene expression and deleterious recombination and could play a key role in modulating genome stability in response to environmental changes. However, very little is known about heterochromatin structure and function in human fungal pathogens. In this review, I use our knowledge of heterochromatin structure and function in fungal model systems as a road map to review the role of heterochromatin in regulating genome plasticity in the most common human fungal pathogens: Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. View Full-Text
Keywords: epigenetics; genome stability; heterochromatin; human fungal pathogens; chromatin modifications epigenetics; genome stability; heterochromatin; human fungal pathogens; chromatin modifications
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Buscaino, A. Chromatin-Mediated Regulation of Genome Plasticity in Human Fungal Pathogens. Genes 2019, 10, 855.

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