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The Mechanisms of Mating in Pathogenic Fungi—A Plastic Trait

Medical Research Council Centre for Medical Mycology, Department of Biosciences, University of Exeter, Geoffrey Pope Building, Exeter EX4 4QD, UK
Genes 2019, 10(10), 831; https://doi.org/10.3390/genes10100831
Received: 30 August 2019 / Revised: 30 September 2019 / Accepted: 17 October 2019 / Published: 21 October 2019
(This article belongs to the Special Issue Genome plasticity of human and plant pathogenic fungi)
The impact of fungi on human and plant health is an ever-increasing issue. Recent studies have estimated that human fungal infections result in an excess of one million deaths per year and plant fungal infections resulting in the loss of crop yields worth approximately 200 million per annum. Sexual reproduction in these economically important fungi has evolved in response to the environmental stresses encountered by the pathogens as a method to target DNA damage. Meiosis is integral to this process, through increasing diversity through recombination. Mating and meiosis have been extensively studied in the model yeast Saccharomyces cerevisiae, highlighting that these mechanisms have diverged even between apparently closely related species. To further examine this, this review will inspect these mechanisms in emerging important fungal pathogens, such as Candida, Aspergillus, and Cryptococcus. It shows that both sexual and asexual reproduction in these fungi demonstrate a high degree of plasticity. View Full-Text
Keywords: mating; meiosis; genomes; MAT (mating type) locus; Candida; Aspergillus; Cryptococcus mating; meiosis; genomes; MAT (mating type) locus; Candida; Aspergillus; Cryptococcus
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Usher, J. The Mechanisms of Mating in Pathogenic Fungi—A Plastic Trait. Genes 2019, 10, 831.

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