Next Article in Journal
Does Siponimod Exert Direct Effects in the Central Nervous System?
Next Article in Special Issue
Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production
Previous Article in Journal
Opposing Roles of S1P3 Receptors in Myocardial Function
Previous Article in Special Issue
Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs Versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice
Review

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

1
Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea
2
Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea
3
Department of Biomedical Science, Daegu Catholic University, Gyeongsan 38430, Korea
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(8), 1773; https://doi.org/10.3390/cells9081773
Received: 22 June 2020 / Revised: 22 July 2020 / Accepted: 22 July 2020 / Published: 24 July 2020
(This article belongs to the Special Issue Insulin-Like Growth Factors in Development, Cancers and Aging)
Skeletal muscle is an essential tissue that attaches to bones and facilitates body movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an important role in skeletal myogenesis and is importantly associated with muscle mass entity, strength development, and degeneration and increases the proliferative capacity of muscle satellite cells (MSCs). IGF-1R is an IGF-1 receptor with a transmembrane location that activates PI3K/Akt signaling and possesses tyrosine kinase activity, and its expression is significant in terms of myoblast proliferation and normal muscle mass maintenance. IGF-1 synthesis is elevated in MSCs of injured muscles and stimulates MSCs proliferation and myogenic differentiation. Mechanical loading also affects skeletal muscle production by IGF-1, and low IGF-1 levels are associated with low handgrip strength and poor physical performance. IGF-1 is potentially useful in the management of Duchenne muscular dystrophy, muscle atrophy, and promotes neurite development. This review highlights the role of IGF-1 in skeletal muscle, its importance during myogenesis, and its involvement in different disease conditions. View Full-Text
Keywords: skeletal muscle; IGF-1; MSCs; myogenesis skeletal muscle; IGF-1; MSCs; myogenesis
Show Figures

Figure 1

MDPI and ACS Style

Ahmad, S.S.; Ahmad, K.; Lee, E.J.; Lee, Y.-H.; Choi, I. Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases. Cells 2020, 9, 1773. https://doi.org/10.3390/cells9081773

AMA Style

Ahmad SS, Ahmad K, Lee EJ, Lee Y-H, Choi I. Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases. Cells. 2020; 9(8):1773. https://doi.org/10.3390/cells9081773

Chicago/Turabian Style

Ahmad, Syed S., Khurshid Ahmad, Eun J. Lee, Yong-Ho Lee, and Inho Choi. 2020. "Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases" Cells 9, no. 8: 1773. https://doi.org/10.3390/cells9081773

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop