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Article

miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data

by
Luiz Augusto Bovolenta
1,*,
Danillo Pinhal
2,
Marcio Luis Acencio
3,
Arthur Casulli de Oliveira
2,
Simon Moxon
4,
Cesar Martins
5 and
Ney Lemke
1
1
Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University—UNESP, Botucatu SP CEP:18618-689, Brazil
2
Department of Chemical and Biological Sciences, Institute of Biosciences of Botucatu, São Paulo State University—UNESP, Botucatu SP CEP:18618-689, Brazil
3
Luxembourg Centre for Systems Biomedicine, Université du Luxembourg, Campus Belval, 7, Avenue das Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Luxembourg
4
School of Biological Sciences, University of East Anglia (UEA), Norwich Research Park, Norwich NR4 7TJ, UK
5
Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University—UNESP, Botucatu SP CEP:18618-689, Brazil
*
Author to whom correspondence should be addressed.
Cells 2020, 9(8), 1752; https://doi.org/10.3390/cells9081752
Submission received: 25 June 2020 / Revised: 16 July 2020 / Accepted: 20 July 2020 / Published: 22 July 2020
(This article belongs to the Special Issue microRNA Bioinformatics)
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Abstract

Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have focused on the multiple roles played by microRNAs (miRNAs) in the post-transcriptional regulation of protein-coding genes involved in the emergence of phenotypes with relevance for aquaculture. However, there is still a growing demand for a reference resource dedicated to integrating Nile Tilapia miRNA information, obtained from both experimental and in silico approaches, and facilitating the analysis and interpretation of RNA sequencing data. Here, we present an open repository dedicated to Nile Tilapia miRNAs: the “miRTil database”. The database stores data on 734 mature miRNAs identified in 11 distinct tissues and five key developmental stages. The database provides detailed information about miRNA structure, genomic context, predicted targets, expression profiles, and relative 5p/3p arm usage. Additionally, miRTil also includes a comprehensive pre-computed miRNA-target interaction network containing 4936 targets and 19,580 interactions.
Keywords: database; microRNA; post-transcriptional regulation; Nile tilapia; microRNA target prediction; microRNA expression profile database; microRNA; post-transcriptional regulation; Nile tilapia; microRNA target prediction; microRNA expression profile

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MDPI and ACS Style

Bovolenta, L.A.; Pinhal, D.; Acencio, M.L.; Oliveira, A.C.d.; Moxon, S.; Martins, C.; Lemke, N. miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data. Cells 2020, 9, 1752. https://doi.org/10.3390/cells9081752

AMA Style

Bovolenta LA, Pinhal D, Acencio ML, Oliveira ACd, Moxon S, Martins C, Lemke N. miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data. Cells. 2020; 9(8):1752. https://doi.org/10.3390/cells9081752

Chicago/Turabian Style

Bovolenta, Luiz Augusto, Danillo Pinhal, Marcio Luis Acencio, Arthur Casulli de Oliveira, Simon Moxon, Cesar Martins, and Ney Lemke. 2020. "miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data" Cells 9, no. 8: 1752. https://doi.org/10.3390/cells9081752

APA Style

Bovolenta, L. A., Pinhal, D., Acencio, M. L., Oliveira, A. C. d., Moxon, S., Martins, C., & Lemke, N. (2020). miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data. Cells, 9(8), 1752. https://doi.org/10.3390/cells9081752

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