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Review

Dysregulation of TCTP in Biological Processes and Diseases

1
School of Medicine, Faculty of Science, Medicine & Health, University of Wollongong, Wollongong, NSW 2522, Australia
2
Institut Gustave Roussy, Unite Inserm U981, 94805 Villejuif, France
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(7), 1632; https://doi.org/10.3390/cells9071632
Received: 19 June 2020 / Revised: 2 July 2020 / Accepted: 3 July 2020 / Published: 7 July 2020
(This article belongs to the Special Issue Role of TCTP in Cell Biological and Disease Processes)
Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF) or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is involved in a range of basic cell biological processes, such as promotion of growth and development, or cellular defense in response to biological stresses. Cellular TCTP levels are highly regulated in response to a variety of physiological signals, and regulatory mechanism at various levels have been elucidated. Given the importance of TCTP in maintaining cellular homeostasis, it is not surprising that dysregulation of this protein is associated with a range of disease processes. Here, we review recent progress that has been made in the characterisation of the basic biological functions of TCTP, in the description of mechanisms involved in regulating its cellular levels and in the understanding of dysregulation of TCTP, as it occurs in disease processes such as cancer. View Full-Text
Keywords: TCTP (HRF; fortilin); growth and development; biological stress reactions; autophagy; regulation of protein synthesis; regulated protein degradation; cancer; cardiovascular diseases TCTP (HRF; fortilin); growth and development; biological stress reactions; autophagy; regulation of protein synthesis; regulated protein degradation; cancer; cardiovascular diseases
MDPI and ACS Style

Bommer, U.-A.; Telerman, A. Dysregulation of TCTP in Biological Processes and Diseases. Cells 2020, 9, 1632. https://doi.org/10.3390/cells9071632

AMA Style

Bommer U-A, Telerman A. Dysregulation of TCTP in Biological Processes and Diseases. Cells. 2020; 9(7):1632. https://doi.org/10.3390/cells9071632

Chicago/Turabian Style

Bommer, Ulrich-Axel, and Adam Telerman. 2020. "Dysregulation of TCTP in Biological Processes and Diseases" Cells 9, no. 7: 1632. https://doi.org/10.3390/cells9071632

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