Next Article in Journal
Notch-Inflammation Networks in Regulation of Breast Cancer Progression
Previous Article in Journal
NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy
Open AccessReview

Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story

by Ugo Ala
Department of Veterinary Sciences, University of Turin, 10124 Turin, Italy
Cells 2020, 9(7), 1574; https://doi.org/10.3390/cells9071574
Received: 28 May 2020 / Revised: 18 June 2020 / Accepted: 23 June 2020 / Published: 28 June 2020
MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and non-coding RNA molecules can be targeted by the same miRNAs and can indirectly regulate each other by competing for them. These RNAs, otherwise known as competing endogenous RNAs (ceRNAs), lead to an additional post-transcriptional regulatory layer, where non-coding RNAs can find new significance. The miRNA-mediated interplay among different types of RNA molecules has been observed in many different contexts. The analyses of ceRNA networks in cancer and other pathologies, as well as in other physiological conditions, provide new opportunities for interpreting omics data for the field of personalized medicine. The development of novel computational tools, providing putative predictions of ceRNA interactions, is a rapidly growing field of interest. In this review, I discuss and present the current knowledge of the ceRNA mechanism and its implications in a broad spectrum of different pathologies, such as cardiovascular or autoimmune diseases, cancers and neurodegenerative disorders. View Full-Text
Keywords: competing endogenous RNAs; ceRNA mechanism; miRNA; non-coding RNAs; cancer; cardiovascular pathologies; neurodegenerative disorders competing endogenous RNAs; ceRNA mechanism; miRNA; non-coding RNAs; cancer; cardiovascular pathologies; neurodegenerative disorders
Show Figures

Figure 1

MDPI and ACS Style

Ala, U. Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story. Cells 2020, 9, 1574.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop