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Review

Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer

1
Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India
2
Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518005, China
3
Shenzhen Bay Laboratory, Shenzhen 518055, China
4
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
5
Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University, Sector-125, Noida 201313, India
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(6), 1511; https://doi.org/10.3390/cells9061511
Received: 28 May 2020 / Revised: 17 June 2020 / Accepted: 19 June 2020 / Published: 21 June 2020
Triple-negative breast cancer (TNBC) is one of the most lethal forms of breast cancer (BC), with a significant disease burden worldwide. Chemoresistance and lack of targeted therapeutics are major hindrances to effective treatments in the clinic and are crucial causes of a worse prognosis and high rate of relapse/recurrence in patients diagnosed with TNBC. In the last decade, long non-coding RNAs (lncRNAs) have been found to perform a pivotal role in most cellular functions. The aberrant functional expression of lncRNAs plays an ever-increasing role in the progression of diverse malignancies, including TNBC. Therefore, lncRNAs have been recently studied as predictors and modifiers of chemoresistance. Our review discusses the potential involvement of lncRNAs in drug-resistant mechanisms commonly found in TNBC and highlights various therapeutic strategies to target lncRNAs in this malignancy. View Full-Text
Keywords: long non-coding RNA (lncRNA); triple-negative breast cancer (TNBC); chemoresistance; acquired drug resistance; oncotherapeutics long non-coding RNA (lncRNA); triple-negative breast cancer (TNBC); chemoresistance; acquired drug resistance; oncotherapeutics
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MDPI and ACS Style

Kansara, S.; Pandey, V.; Lobie, P.E.; Sethi, G.; Garg, M.; Pandey, A.K. Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer. Cells 2020, 9, 1511. https://doi.org/10.3390/cells9061511

AMA Style

Kansara S, Pandey V, Lobie PE, Sethi G, Garg M, Pandey AK. Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer. Cells. 2020; 9(6):1511. https://doi.org/10.3390/cells9061511

Chicago/Turabian Style

Kansara, Samarth, Vijay Pandey, Peter E. Lobie, Gautam Sethi, Manoj Garg, and Amit K. Pandey. 2020. "Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer" Cells 9, no. 6: 1511. https://doi.org/10.3390/cells9061511

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