Rab27a Contributes to the Processing of Inflammatory Pain in Mice
1
Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438 Frankfurt am Main, Germany
2
Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, 60596 Frankfurt am Main, Germany
3
Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK
4
CEDOC, NOVA Medical School, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal
5
Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, 60595 Frankfurt am Main, Germany
*
Author to whom correspondence should be addressed.
†
These authors have contributed equally to this work.
Cells 2020, 9(6), 1488; https://doi.org/10.3390/cells9061488
Received: 14 April 2020 / Revised: 13 June 2020 / Accepted: 15 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue Novel Insights into Molecular Mechanisms of Chronic Pain)
Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of evidence indicates that members of the Rab family of small GTPases contribute to pain processing; however, their specific functions remain poorly understood. Here, we found using immunofluorescence staining and in situ hybridization that the small GTPase Rab27a is highly expressed in sensory neurons and in the superficial dorsal horn of the spinal cord of mice. Rab27a mutant mice, which carry a single-nucleotide missense mutation of Rab27a leading to the expression of a nonfunctional protein, show reduced mechanical hyperalgesia and spontaneous pain behavior in inflammatory pain models, while their responses to acute noxious mechanical and thermal stimuli is not affected. Our study uncovers a previously unrecognized function of Rab27a in the processing of persistent inflammatory pain in mice.
View Full-Text
Keywords:
Rab27a; inflammatory pain; spinal cord; dorsal root ganglia; mice
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Gross, T.; Wack, G.; Syhr, K.M.J.; Tolmachova, T.; Seabra, M.C.; Geisslinger, G.; Niederberger, E.; Schmidtko, A.; Kallenborn-Gerhardt, W. Rab27a Contributes to the Processing of Inflammatory Pain in Mice. Cells 2020, 9, 1488.
AMA Style
Gross T, Wack G, Syhr KMJ, Tolmachova T, Seabra MC, Geisslinger G, Niederberger E, Schmidtko A, Kallenborn-Gerhardt W. Rab27a Contributes to the Processing of Inflammatory Pain in Mice. Cells. 2020; 9(6):1488.
Chicago/Turabian StyleGross, Tilman; Wack, Gesine; Syhr, Katharina M.J.; Tolmachova, Tanya; Seabra, Miguel C.; Geisslinger, Gerd; Niederberger, Ellen; Schmidtko, Achim; Kallenborn-Gerhardt, Wiebke. 2020. "Rab27a Contributes to the Processing of Inflammatory Pain in Mice" Cells 9, no. 6: 1488.
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit
