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Rab27a Contributes to the Processing of Inflammatory Pain in Mice

Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438 Frankfurt am Main, Germany
Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, 60596 Frankfurt am Main, Germany
Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK
CEDOC, NOVA Medical School, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal
Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, 60595 Frankfurt am Main, Germany
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Cells 2020, 9(6), 1488;
Received: 14 April 2020 / Revised: 13 June 2020 / Accepted: 15 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue Novel Insights into Molecular Mechanisms of Chronic Pain)
Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of evidence indicates that members of the Rab family of small GTPases contribute to pain processing; however, their specific functions remain poorly understood. Here, we found using immunofluorescence staining and in situ hybridization that the small GTPase Rab27a is highly expressed in sensory neurons and in the superficial dorsal horn of the spinal cord of mice. Rab27a mutant mice, which carry a single-nucleotide missense mutation of Rab27a leading to the expression of a nonfunctional protein, show reduced mechanical hyperalgesia and spontaneous pain behavior in inflammatory pain models, while their responses to acute noxious mechanical and thermal stimuli is not affected. Our study uncovers a previously unrecognized function of Rab27a in the processing of persistent inflammatory pain in mice. View Full-Text
Keywords: Rab27a; inflammatory pain; spinal cord; dorsal root ganglia; mice Rab27a; inflammatory pain; spinal cord; dorsal root ganglia; mice
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MDPI and ACS Style

Gross, T.; Wack, G.; Syhr, K.M.J.; Tolmachova, T.; Seabra, M.C.; Geisslinger, G.; Niederberger, E.; Schmidtko, A.; Kallenborn-Gerhardt, W. Rab27a Contributes to the Processing of Inflammatory Pain in Mice. Cells 2020, 9, 1488.

AMA Style

Gross T, Wack G, Syhr KMJ, Tolmachova T, Seabra MC, Geisslinger G, Niederberger E, Schmidtko A, Kallenborn-Gerhardt W. Rab27a Contributes to the Processing of Inflammatory Pain in Mice. Cells. 2020; 9(6):1488.

Chicago/Turabian Style

Gross, Tilman, Gesine Wack, Katharina M.J. Syhr, Tanya Tolmachova, Miguel C. Seabra, Gerd Geisslinger, Ellen Niederberger, Achim Schmidtko, and Wiebke Kallenborn-Gerhardt. 2020. "Rab27a Contributes to the Processing of Inflammatory Pain in Mice" Cells 9, no. 6: 1488.

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