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Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain

1
Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD 21201, USA
2
Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD 21201, USA
3
Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD 21201, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Cells 2020, 9(5), 1194; https://doi.org/10.3390/cells9051194
Received: 21 April 2020 / Revised: 8 May 2020 / Accepted: 8 May 2020 / Published: 11 May 2020
(This article belongs to the Special Issue Novel Insights into Molecular Mechanisms of Chronic Pain)
Brain-derived neurotrophic factor (BDNF), a major focus for regenerative therapeutics, has been lauded for its pro-survival characteristics and involvement in both development and recovery of function within the central nervous system (CNS). However, studies of tyrosine receptor kinase B (TrkB), a major receptor for BDNF, indicate that certain effects of the TrkB receptor in response to disease or injury may be maladaptive. More specifically, imbalance among TrkB receptor isoforms appears to contribute to aberrant signaling and hyperpathic pain. A truncated isoform of the receptor, TrkB.T1, lacks the intracellular kinase domain of the full length receptor and is up-regulated in multiple CNS injury models. Such up-regulation is associated with hyperpathic pain, and TrkB.T1 inhibition reduces neuropathic pain in various experimental paradigms. Deletion of TrkB.T1 also limits astrocyte changes in vitro, including proliferation, migration, and activation. Mechanistically, TrkB.T1 is believed to act through release of intracellular calcium in astrocytes, as well as through interactions with neurotrophins, leading to cell cycle activation. Together, these studies support a potential role for astrocytic TrkB.T1 in hyperpathic pain and suggest that targeted strategies directed at this receptor may have therapeutic potential. View Full-Text
Keywords: tyrosine receptor kinase B (TrkB); TrkB.T1; brain-derived neurotrophic factor (BDNF); astrocytes; neuropathic pain; spinal cord injury tyrosine receptor kinase B (TrkB); TrkB.T1; brain-derived neurotrophic factor (BDNF); astrocytes; neuropathic pain; spinal cord injury
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MDPI and ACS Style

Cao, T.; Matyas, J.J.; Renn, C.L.; Faden, A.I.; Dorsey, S.G.; Wu, J. Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain. Cells 2020, 9, 1194. https://doi.org/10.3390/cells9051194

AMA Style

Cao T, Matyas JJ, Renn CL, Faden AI, Dorsey SG, Wu J. Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain. Cells. 2020; 9(5):1194. https://doi.org/10.3390/cells9051194

Chicago/Turabian Style

Cao, Tuoxin; Matyas, Jessica J.; Renn, Cynthia L.; Faden, Alan I.; Dorsey, Susan G.; Wu, Junfang. 2020. "Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain" Cells 9, no. 5: 1194. https://doi.org/10.3390/cells9051194

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