Hepatitis B Virus Entry into Cells
1
Inserm U1259, Morphogénèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours and CHRU de Tours, 37032 Tours, France
2
Plate-Forme IBiSA des Microscopies, PPF ASB, Université de Tours and CHRU de Tours, 37032 Tours, France
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(6), 1486; https://doi.org/10.3390/cells9061486
Received: 18 May 2020
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Revised: 15 June 2020
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Accepted: 16 June 2020
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Published: 18 June 2020
(This article belongs to the Section Cellular Pathology)
Hepatitis B virus (HBV), an enveloped partially double-stranded DNA virus, is a widespread human pathogen responsible for more than 250 million chronic infections worldwide. Current therapeutic strategies cannot eradicate HBV due to the persistence of the viral genome in a special DNA structure (covalently closed circular DNA, cccDNA). The identification of sodium taurocholate co-transporting polypeptide (NTCP) as an entry receptor for both HBV and its satellite virus hepatitis delta virus (HDV) has led to great advances in our understanding of the life cycle of HBV, including the early steps of infection in particular. However, the mechanisms of HBV internalization and the host factors involved in this uptake remain unclear. Improvements in our understanding of HBV entry would facilitate the design of new therapeutic approaches targeting this stage and preventing the de novo infection of naïve hepatocytes. In this review, we provide an overview of current knowledge about the process of HBV internalization into cells.
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Keywords:
Hepatitis B virus; virus–host interaction; entry pathway
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MDPI and ACS Style
Herrscher, C.; Roingeard, P.; Blanchard, E. Hepatitis B Virus Entry into Cells. Cells 2020, 9, 1486. https://doi.org/10.3390/cells9061486
AMA Style
Herrscher C, Roingeard P, Blanchard E. Hepatitis B Virus Entry into Cells. Cells. 2020; 9(6):1486. https://doi.org/10.3390/cells9061486
Chicago/Turabian StyleHerrscher, Charline, Philippe Roingeard, and Emmanuelle Blanchard. 2020. "Hepatitis B Virus Entry into Cells" Cells 9, no. 6: 1486. https://doi.org/10.3390/cells9061486
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