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Review

Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine

by
Karolina Wydra
1,
Dawid Gawliński
1,
Kinga Gawlińska
1,
Małgorzata Frankowska
1,
Dasiel O. Borroto-Escuela
2,3,4,
Kjell Fuxe
2 and
Małgorzata Filip
1,*
1
Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Kraków, Poland
2
Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
3
Section of Physiology, Department of Biomolecular Science, University of Urbino, Campus Scientifico Enrico Mattei, Via Ca’ Le Suore 2, 61029 Urbino, Italy
4
Observatorio Cubano de Neurociencias, Grupo Bohío-Estudio, Zayas 50, Yaguajay 62100, Cuba
*
Author to whom correspondence should be addressed.
Cells 2020, 9(6), 1372; https://doi.org/10.3390/cells9061372
Submission received: 5 May 2020 / Revised: 28 May 2020 / Accepted: 28 May 2020 / Published: 1 June 2020
(This article belongs to the Special Issue Adenosine Receptors: From Cell Biology to Human Diseases)
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Abstract

Several psychoactive drugs can evoke substance use disorders (SUD) in humans and animals, and these include psychostimulants, opioids, cannabinoids (CB), nicotine, and alcohol. The etiology, mechanistic processes, and the therapeutic options to deal with SUD are not well understood. The common feature of all abused drugs is that they increase dopamine (DA) neurotransmission within the mesocorticolimbic circuitry of the brain followed by the activation of DA receptors. D2 receptors were proposed as important molecular targets for SUD. The findings showed that D2 receptors formed heteromeric complexes with other GPCRs, which forced the addiction research area in new directions. In this review, we updated the view on the brain D2 receptor complexes with adenosine (A)2A receptors (A2AR) and discussed the role of A2AR in different aspects of addiction phenotypes in laboratory animal procedures that permit the highly complex syndrome of human drug addiction. We presented the current knowledge on the neurochemical in vivo and ex vivo mechanisms related to cocaine use disorder (CUD) and discussed future research directions for A2AR heteromeric complexes in SUD.
Keywords: adenosine (A)2 receptors; A2A-D2 receptor interaction; behavioral effects; drugs of abuse; laboratory animals; neurochemistry; striatum; substance use disorder adenosine (A)2 receptors; A2A-D2 receptor interaction; behavioral effects; drugs of abuse; laboratory animals; neurochemistry; striatum; substance use disorder

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MDPI and ACS Style

Wydra, K.; Gawliński, D.; Gawlińska, K.; Frankowska, M.; Borroto-Escuela, D.O.; Fuxe, K.; Filip, M. Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine. Cells 2020, 9, 1372. https://doi.org/10.3390/cells9061372

AMA Style

Wydra K, Gawliński D, Gawlińska K, Frankowska M, Borroto-Escuela DO, Fuxe K, Filip M. Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine. Cells. 2020; 9(6):1372. https://doi.org/10.3390/cells9061372

Chicago/Turabian Style

Wydra, Karolina, Dawid Gawliński, Kinga Gawlińska, Małgorzata Frankowska, Dasiel O. Borroto-Escuela, Kjell Fuxe, and Małgorzata Filip. 2020. "Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine" Cells 9, no. 6: 1372. https://doi.org/10.3390/cells9061372

APA Style

Wydra, K., Gawliński, D., Gawlińska, K., Frankowska, M., Borroto-Escuela, D. O., Fuxe, K., & Filip, M. (2020). Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine. Cells, 9(6), 1372. https://doi.org/10.3390/cells9061372

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