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From Tank to Treatment: Modeling Melanoma in Zebrafish

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Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
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Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
*
Author to whom correspondence should be addressed.
Cells 2020, 9(5), 1289; https://doi.org/10.3390/cells9051289
Received: 9 April 2020 / Revised: 16 May 2020 / Accepted: 18 May 2020 / Published: 22 May 2020
Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish—due in large part to their tractable genetics, conserved pathways, and optical properties—have emerged as an excellent system to model melanoma. Zebrafish have been used to study melanoma from a single tumor initiating cell, through metastasis, remission, and finally into relapse. In this review, we examine seminal zebrafish studies that have advanced our understanding of melanoma. View Full-Text
Keywords: Melanoma; zebrafish; melanocytes; modeling; genetics; microenvironment; xenografts Melanoma; zebrafish; melanocytes; modeling; genetics; microenvironment; xenografts
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Frantz, W.T.; Ceol, C.J. From Tank to Treatment: Modeling Melanoma in Zebrafish. Cells 2020, 9, 1289.

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