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Epigenetic Requirements for Triggering Heterochromatinization and Piwi-Interacting RNA Production from Transgenes in the Drosophila Germline

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Open AccessFeature PaperReview

Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes

Inserm, Faculté de Médecine, CRBC, GReD Institute, Université Clermont Auvergne, CNRS, 28 place Henri Dunant, TSA 50400, CEDEX 1, 63001 Clermont-Ferrand, France
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Cells 2020, 9(5), 1172; https://doi.org/10.3390/cells9051172
Received: 27 April 2020 / Revised: 5 May 2020 / Accepted: 7 May 2020 / Published: 8 May 2020
(This article belongs to the Special Issue Evolution of Epigenetic Mechanisms and Signatures)
Transposable elements (TEs) are long-term residents of eukaryotic genomes that make up a large portion of these genomes. They can be considered as perfectly fine members of genomes replicating with resident genes and being transmitted vertically to the next generation. However, unlike regular genes, TEs have the ability to send new copies to new sites. As such, they have been considered as parasitic members ensuring their own replication. In another view, TEs may also be considered as symbiotic sequences providing shared benefits after mutualistic interactions with their host genome. In this review, we recall the relationship between TEs and their host genome and discuss why transient relaxation of TE silencing within specific developmental windows may be useful for both.
Keywords: retroelements; transposable elements; piRNAs; DNA methylation; KRAB complex; silencing; germline; DRTS; Pilp retroelements; transposable elements; piRNAs; DNA methylation; KRAB complex; silencing; germline; DRTS; Pilp
MDPI and ACS Style

Maupetit-Mehouas, S.; Vaury, C. Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes. Cells 2020, 9, 1172.

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