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Review

Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges

1
Faculty of Medicine, University of Latvia, House of Science, Jelgavas Str 3, LV-1004 Riga, Latvia
2
Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, Norway
3
Latvian Biomedical Research and Study Centre, Ratsupites Str 1, k-1, LV-1067 Riga, Latvia
*
Author to whom correspondence should be addressed.
Cells 2020, 9(5), 1171; https://doi.org/10.3390/cells9051171
Received: 23 April 2020 / Revised: 5 May 2020 / Accepted: 6 May 2020 / Published: 8 May 2020
(This article belongs to the Special Issue Therapeutic Applications of Extracellular Vesicles)
Adult stem cells (SCs) participate in tissue repair and homeostasis regulation. The relative ease of SC handling and their therapeutic effect has made of these cell popular candidates for cellular therapy. However, several problems interfere with their clinical application in cancer treatment, like safety issues, unpredictable pro-tumour effects, and tissue entrapment. Therefore cell-free therapies that exhibit SC properties are being investigated. It is now well known that adult SCs exhibit their therapeutic effect via paracrine mechanisms. In addition to secretory proteins, SCs also release extracellular vesicles (EV) that deliver their contents to the target cells. Cancer treatment is one of the most promising applications of SC-EVs. Moreover, SC-EVs could be modified to improve targeted drug delivery. The aim of the review is to summarise current knowledge of adult SC-EV application in cancer treatment and to emphasise future opportunities and challenges in cancer treatment. View Full-Text
Keywords: extracellular vesicles; mesenchymal stromal cells; cancer treatment extracellular vesicles; mesenchymal stromal cells; cancer treatment
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MDPI and ACS Style

Parfejevs, V.; Sagini, K.; Buss, A.; Sobolevska, K.; Llorente, A.; Riekstina, U.; Abols, A. Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges. Cells 2020, 9, 1171. https://doi.org/10.3390/cells9051171

AMA Style

Parfejevs V, Sagini K, Buss A, Sobolevska K, Llorente A, Riekstina U, Abols A. Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges. Cells. 2020; 9(5):1171. https://doi.org/10.3390/cells9051171

Chicago/Turabian Style

Parfejevs, Vadims, Krizia Sagini, Arturs Buss, Kristine Sobolevska, Alicia Llorente, Una Riekstina, and Arturs Abols. 2020. "Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges" Cells 9, no. 5: 1171. https://doi.org/10.3390/cells9051171

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