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Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis

Laboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, France
Univ. Lille, Inserm, U1003 – PHYCEL – Physiologie Cellulaire, F-59000 Lille, France
Author to whom correspondence should be addressed.
Cells 2020, 9(2), 317;
Received: 14 October 2019 / Revised: 8 January 2020 / Accepted: 21 January 2020 / Published: 28 January 2020
(This article belongs to the Special Issue Organellar Calcium Signaling in Physiology and Pathophysiology)
It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells. Modulation of TRPV channels activity can modify their physiological function leading to some diseases and disorders like neurodegeneration, pain, cancer, skin disorders, etc. It should be noted that, despite TRPV channels importance, our knowledge of the TRPV channels functions in cells is mostly limited to their plasma membrane location. However, some TRPV channels were shown to be expressed in the endoplasmic reticulum where their modulation by activators and/or inhibitors was demonstrated to be crucial for intracellular signaling. In this review, we have intended to summarize the poorly studied roles and functions of these channels in the endoplasmic reticulum. View Full-Text
Keywords: TRPV channels; endoplasmic reticulum; calcium signaling TRPV channels; endoplasmic reticulum; calcium signaling
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MDPI and ACS Style

Haustrate, A.; Prevarskaya, N.; Lehen’kyi, V. Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis. Cells 2020, 9, 317.

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