Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis
by
Anca Raluca Dinu 1,†, 
Alexandru Florin Rogobete 1,2,†
, Tiberiu Bratu 1,*, Sonia Elena Popovici 1,2, Ovidiu Horea Bedreag 1,2,*, Marius Papurica 1,2,†, Lavinia Melania Bratu 1 and Dorel Sandesc 1,2
Anca Raluca Dinu 1,†, Alexandru Florin Rogobete 1,2,†, Tiberiu Bratu 1,*, Sonia Elena Popovici 1,2, Ovidiu Horea Bedreag 1,2,*, Marius Papurica 1,2,†, Lavinia Melania Bratu 1 and Dorel Sandesc 1,2
1
Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
2
Clinic of Anaesthesia and Intensive Care, Emergency County Hospital “Pius Brinzeu”, 325100 Timisoara, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this paper.
Cells 2020, 9(2), 307; https://doi.org/10.3390/cells9020307
Received: 7 November 2019 / Revised: 24 January 2020 / Accepted: 26 January 2020 / Published: 28 January 2020
(This article belongs to the Special Issue microRNA as Biomarker)
Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. The aim of this review paper was to present, in detail, the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, we wish to present the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression.
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Keywords:
sepsis; endocannabinoid system; cannabinoids; cannabis sativa; THC; CBD
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Doi: doi: 10.20944/preprints201911.0260.v1
MDPI and ACS Style
Dinu, A.R.; Rogobete, A.F.; Bratu, T.; Popovici, S.E.; Bedreag, O.H.; Papurica, M.; Bratu, L.M.; Sandesc, D. Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis. Cells 2020, 9, 307.
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