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Biological Functions and Analytical Strategies of Sialic Acids in Tumor

by Xiaoman Zhou 1, Ganglong Yang 1,* and Feng Guan 1,2,*
1
The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
2
Joint International Research Laboratory of Glycobiology and Medicinal Chemistry, College of Life Science, Northwest University, Xi’an 710069, China
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(2), 273; https://doi.org/10.3390/cells9020273 (registering DOI)
Received: 18 November 2019 / Revised: 17 January 2020 / Accepted: 21 January 2020 / Published: 22 January 2020
(This article belongs to the Special Issue Glycosylation and Cell Biology)
Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell–cell communication, bacterial and viral infections. In particular, hypersialylation in tumors, as well as their roles in tumor growth and metastasis, have been widely described. Recent studies have indicated that the aberrant sialylation is a vital way for tumor cells to escape immune surveillance and keep malignance. In this article, we outline the present state of knowledge on the metabolic pathway of human sialic acids, the function of hypersialylation in tumors, as well as the recent labeling and analytical techniques for sialic acids. It is expected to offer a brief introduction of sialic acid metabolism and provide advanced analytical strategies in sialic acid studies. View Full-Text
Keywords: sialic acid; sialyltransferase; sialidase; tumor sialylation; sialic acid labeling sialic acid; sialyltransferase; sialidase; tumor sialylation; sialic acid labeling
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Zhou, X.; Yang, G.; Guan, F. Biological Functions and Analytical Strategies of Sialic Acids in Tumor. Cells 2020, 9, 273.

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