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Article

Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia

1
Innovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, Germany
2
Department of Radiation Oncology, University of Leipzig, 04103 Leipzig, Germany
3
Institute for Medical Science and Technology (IMSaT), University of Dundee, Dundee DD2 1FD, UK
*
Authors to whom correspondence should be addressed.
Zhang and Hu share equal contribution.
Cells 2020, 9(12), 2595; https://doi.org/10.3390/cells9122595
Received: 5 October 2020 / Revised: 24 November 2020 / Accepted: 1 December 2020 / Published: 3 December 2020
(This article belongs to the Special Issue Cancer Cell Response to Radiation Therapy)
Focused ultrasound (FUS) has become an important non-invasive therapy for solid tumor ablation via thermal effects. The cavitation effect induced by FUS is thereby avoided but applied for lithotripsy, support drug delivery and the induction of blood vessel destruction for cancer therapy. In this study, head and neck cancer (FaDu), glioblastoma (T98G), and prostate cancer (PC-3) cells were exposed to FUS by using an in vitro FUS system followed by single-dose X-ray radiation therapy (RT) or water bath hyperthermia (HT). Sensitization effects of short FUS shots with cavitation (FUS-Cav) or without cavitation (FUS) to RT or HT (45 °C, 30 min) were evaluated. FUS-Cav significantly increases the sensitivity of cancer cells to RT and HT by reducing long-term clonogenic survival, short-term cell metabolic activity, cell invasion, and induction of sonoporation. Our results demonstrated that short FUS treatment with cavitation has good potential to sensitize cancer cells to RT and HT non-invasively.
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Keywords: focused ultrasound; cavitation; radiation therapy; hyperthermia; sensitization focused ultrasound; cavitation; radiation therapy; hyperthermia; sensitization
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MDPI and ACS Style

Hu, S.; Zhang, X.; Unger, M.; Patties, I.; Melzer, A.; Landgraf, L. Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia. Cells 2020, 9, 2595. https://doi.org/10.3390/cells9122595

AMA Style

Hu S, Zhang X, Unger M, Patties I, Melzer A, Landgraf L. Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia. Cells. 2020; 9(12):2595. https://doi.org/10.3390/cells9122595

Chicago/Turabian Style

Hu, Shaonan, Xinrui Zhang, Michael Unger, Ina Patties, Andreas Melzer, and Lisa Landgraf. 2020. "Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia" Cells 9, no. 12: 2595. https://doi.org/10.3390/cells9122595

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