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Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments

College of Pharmacy, Dongguk University, Seoul 04620, Korea
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Author to whom correspondence should be addressed.
Cells 2020, 9(11), 2352; https://doi.org/10.3390/cells9112352
Received: 29 September 2020 / Revised: 23 October 2020 / Accepted: 24 October 2020 / Published: 25 October 2020
(This article belongs to the Special Issue New Aspects of Targeting Cancer Metabolism in Therapeutic Approach)
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy. View Full-Text
Keywords: farnesyl-diphosphate farnesyltransferase 1; prognostic marker; lipid rafts; cholesterol synthesis; tumour progression farnesyl-diphosphate farnesyltransferase 1; prognostic marker; lipid rafts; cholesterol synthesis; tumour progression
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Ha, N.T.; Lee, C.H. Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments. Cells 2020, 9, 2352.

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