Next Article in Journal
Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase
Previous Article in Journal
Zinc Finger Transcription Factor MZF1—A Specific Regulator of Cancer Invasion
Previous Article in Special Issue
Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections
Open AccessReview

Extracellular Vesicles for Cancer Therapy: Impact of Host Immune Response

1
Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway (NUIG), H91 YR71 Galway, Ireland
2
CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway (NUIG), H91 W2TY Galway, Ireland
*
Author to whom correspondence should be addressed.
Cells 2020, 9(1), 224; https://doi.org/10.3390/cells9010224
Received: 4 December 2019 / Revised: 13 January 2020 / Accepted: 14 January 2020 / Published: 16 January 2020
(This article belongs to the Special Issue Therapeutic Applications of Extracellular Vesicles)
In recent times, extracellular vesicles (EVs) have come under the spotlight as potential therapeutics for cancer, due to the relative ease of manipulation of contents and potential for tumor targeting. The use of EVs as delivery vehicles may bypass some of the negative effects associated with cell-based carriers, and there has been a major focus on defining EV subtypes, establishing transparent nomenclature, and isolation and characterization techniques. EVs are believed to be a fingerprint of the secreting cell and so researchers harness the positive aspects of a particular cell of origin, and can then further modify EV contents to improve therapeutic efficacy. In this review, we highlight studies employing EVs as cancer therapeutics that have reported on immune response. As we rapidly advance towards potential application in the clinical setting, the question of immune response to EV administration in the cancer setting has become critically important. View Full-Text
Keywords: extracellular vesicles; immune response; cancer extracellular vesicles; immune response; cancer
Show Figures

Figure 1

MDPI and ACS Style

Gilligan, K.E.; Dwyer, R.M. Extracellular Vesicles for Cancer Therapy: Impact of Host Immune Response. Cells 2020, 9, 224.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop