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Open AccessFeature PaperReview

Zinc Finger Transcription Factor MZF1—A Specific Regulator of Cancer Invasion

1
Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark
2
Danish Medicines Council, Dampfærgevej 27-29, 2100 Copenhagen, Denmark
3
Department of Drug Design and Pharmacology, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Cells 2020, 9(1), 223; https://doi.org/10.3390/cells9010223
Received: 12 December 2019 / Revised: 8 January 2020 / Accepted: 14 January 2020 / Published: 16 January 2020
(This article belongs to the Special Issue Killing Cancer: Discovery and Selection of New Target Molecules)
Over 90% of cancer deaths are due to cancer cells metastasizing into other organs. Invasion is a prerequisite for metastasis formation. Thus, inhibition of invasion can be an efficient way to prevent disease progression in these patients. This could be achieved by targeting the molecules regulating invasion. One of these is an oncogenic transcription factor, Myeloid Zinc Finger 1 (MZF1). Dysregulated transcription factors represent a unique, increasing group of drug targets that are responsible for aberrant gene expression in cancer and are important nodes driving cancer malignancy. Recent studies report of a central involvement of MZF1 in the invasion and metastasis of various solid cancers. In this review, we summarize the research on MZF1 in cancer including its function and role in lysosome-mediated invasion and in the expression of genes involved in epithelial to mesenchymal transition. We also discuss possible means to target it on the basis of the current knowledge of its function in cancer. View Full-Text
Keywords: cancer therapy; EMT; lysosome; lysosome-mediated invasion; MZF1; phosphorylation; PAK4; SUMOylation; transcription factor; zinc finger cancer therapy; EMT; lysosome; lysosome-mediated invasion; MZF1; phosphorylation; PAK4; SUMOylation; transcription factor; zinc finger
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MDPI and ACS Style

Brix, D.M.; Bundgaard Clemmensen, K.K.; Kallunki, T. Zinc Finger Transcription Factor MZF1—A Specific Regulator of Cancer Invasion. Cells 2020, 9, 223.

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