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Brief Report

Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis

1
Hospital Dr Peset, FISABIO, 46017 Valencia, Spain
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Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, 46010 Valencia, Spain
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Departamento de Farmacología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain
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Departamento de Medicina, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain
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Departamento de Cirugía del Aparato Digestivo, Hospital La Fe, 46526 Valencia, Spain
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Departamento de Cirugía y Coloproctología, Hospital de Manises, 46940 Valencia, Spain
*
Author to whom correspondence should be addressed.
Cells 2019, 8(9), 1078; https://doi.org/10.3390/cells8091078
Received: 13 August 2019 / Revised: 4 September 2019 / Accepted: 11 September 2019 / Published: 13 September 2019
(This article belongs to the Section Autophagy)
We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis. View Full-Text
Keywords: intestinal fibrosis; autophagy; inflammation intestinal fibrosis; autophagy; inflammation
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MDPI and ACS Style

Cosin-Roger, J.; Canet, F.; Macias-Ceja, D.C.; Gisbert-Ferrándiz, L.; Ortiz-Masiá, D.; Esplugues, J.V.; Alós, R.; Navarro, F.; Barrachina, M.D.; Calatayud, S. Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis. Cells 2019, 8, 1078. https://doi.org/10.3390/cells8091078

AMA Style

Cosin-Roger J, Canet F, Macias-Ceja DC, Gisbert-Ferrándiz L, Ortiz-Masiá D, Esplugues JV, Alós R, Navarro F, Barrachina MD, Calatayud S. Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis. Cells. 2019; 8(9):1078. https://doi.org/10.3390/cells8091078

Chicago/Turabian Style

Cosin-Roger, Jesus, Francisco Canet, Dulce C. Macias-Ceja, Laura Gisbert-Ferrándiz, Dolores Ortiz-Masiá, Juan V. Esplugues, Rafael Alós, Francisco Navarro, María D. Barrachina, and Sara Calatayud. 2019. "Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis" Cells 8, no. 9: 1078. https://doi.org/10.3390/cells8091078

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