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Zebrafish in Inflammasome Research

Institute of Biology Leiden, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
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Cells 2019, 8(8), 901; https://doi.org/10.3390/cells8080901
Received: 30 July 2019 / Revised: 13 August 2019 / Accepted: 13 August 2019 / Published: 15 August 2019
(This article belongs to the Special Issue Mechanisms of Inflammasome Activation)
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Abstract

Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function in vivo have started to emerge. Here, we discuss inflammasome research in zebrafish in light of current knowledge about mammalian inflammasomes. We summarize the evolutionary conservation of inflammasome components between zebrafish and mammals, highlighting the similarities and possible divergence in functions of these components. We present new insights into the evolution of the caspase-1 family in the teleost lineage, and how its evolutionary origin may help contextualize its functions. We also review existing infectious and non-infectious models in zebrafish in which inflammasomes have been directly implicated. Finally, we discuss the advantages of zebrafish larvae for intravital imaging of inflammasome activation and summarize available tools that will help to advance inflammasome research. View Full-Text
Keywords: inflammasome; zebrafish; inflammatory caspases; gasdermin; evolutionary conservation; pyroptosis; intravital imaging; animal models inflammasome; zebrafish; inflammatory caspases; gasdermin; evolutionary conservation; pyroptosis; intravital imaging; animal models
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Forn-Cuní, G.; Meijer, A.H.; Varela, M. Zebrafish in Inflammasome Research. Cells 2019, 8, 901.

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