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Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

1
Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, CH-8057 Zurich, Switzerland
2
Molecular Life Science Ph.D. Program, Life Science Zurich Graduate School, CH-8057 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 890; https://doi.org/10.3390/cells8080890
Received: 18 July 2019 / Revised: 9 August 2019 / Accepted: 11 August 2019 / Published: 13 August 2019
(This article belongs to the Special Issue Molecular Role of PARP in Health and Disease)
PDF [1486 KB, uploaded 21 August 2019]

Abstract

Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD+ as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD+-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD+ biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments.
Keywords: carbohydrate metabolism; ADP-ribosylation; ARTD; PARP; NAD+; NR; NMN; NAM carbohydrate metabolism; ADP-ribosylation; ARTD; PARP; NAD+; NR; NMN; NAM
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hopp, A.-K.; Grüter, P.; Hottiger, M.O. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells 2019, 8, 890.

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