Next Article in Journal
Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models
Next Article in Special Issue
The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and Beyond
Previous Article in Journal
Heat Stress-Induced Multiple Multipolar Divisions of Human Cancer Cells
Previous Article in Special Issue
Clinical Development of PARP Inhibitors in Treating Metastatic Castration-Resistant Prostate Cancer
Erratum published on 31 October 2019, see Cells 2019, 8(11), 1371.

Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, CH-8057 Zurich, Switzerland
Molecular Life Science Ph.D. Program, Life Science Zurich Graduate School, CH-8057 Zurich, Switzerland
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 890;
Received: 18 July 2019 / Revised: 9 August 2019 / Accepted: 11 August 2019 / Published: 13 August 2019
(This article belongs to the Special Issue Molecular Role of PARP in Health and Disease)
Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD+ as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD+-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD+ biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments. View Full-Text
Keywords: carbohydrate metabolism; ADP-ribosylation; ARTD; PARP; NAD+; NR; NMN; NAM carbohydrate metabolism; ADP-ribosylation; ARTD; PARP; NAD+; NR; NMN; NAM
Show Figures

Figure 1

MDPI and ACS Style

Hopp, A.-K.; Grüter, P.; Hottiger, M.O. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells 2019, 8, 890.

AMA Style

Hopp A-K, Grüter P, Hottiger MO. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells. 2019; 8(8):890.

Chicago/Turabian Style

Hopp, Ann-Katrin, Patrick Grüter, and Michael O. Hottiger. 2019. "Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation" Cells 8, no. 8: 890.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop