Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation
AbstractCells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD+ as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD+-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD+ biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments. View Full-Text
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Hopp, A.-K.; Grüter, P.; Hottiger, M.O. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells 2019, 8, 890.
Hopp A-K, Grüter P, Hottiger MO. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells. 2019; 8(8):890.Chicago/Turabian Style
Hopp, Ann-Katrin; Grüter, Patrick; Hottiger, Michael O. 2019. "Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation." Cells 8, no. 8: 890.
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