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Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, CH-8057 Zurich, Switzerland
Molecular Life Science Ph.D. Program, Life Science Zurich Graduate School, CH-8057 Zurich, Switzerland
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 890;
Received: 18 July 2019 / Revised: 9 August 2019 / Accepted: 11 August 2019 / Published: 13 August 2019
(This article belongs to the Special Issue Molecular Role of PARP in Health and Disease)
PDF [1486 KB, uploaded 21 August 2019]


Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD+ as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD+-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD+ biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments. View Full-Text
Keywords: carbohydrate metabolism; ADP-ribosylation; ARTD; PARP; NAD+; NR; NMN; NAM carbohydrate metabolism; ADP-ribosylation; ARTD; PARP; NAD+; NR; NMN; NAM

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Hopp, A.-K.; Grüter, P.; Hottiger, M.O. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells 2019, 8, 890.

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