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Circular RNA Regulation of Myogenesis

Department of Biotechnology, College of Life Sciences, Xinyang Normal University, Xinyang 464000, China
Institute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Sciences, Haikou 571100, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(8), 885;
Received: 5 July 2019 / Revised: 4 August 2019 / Accepted: 9 August 2019 / Published: 13 August 2019
PDF [728 KB, uploaded 13 August 2019]


Circular RNA (circRNA) is a novel class of non-coding RNA generated by pre-mRNA back splicing, which is characterized by a closed-loop structure. Although circRNAs were firstly reported decades ago, their regulatory roles have not been discovered until recently. In this review, we discussed the putative biogenesis pathways and regulatory functions of circRNAs. Recent studies showed that circRNAs are abundant in skeletal muscle tissue, and their expression levels are regulated during muscle development and aging. We, thus, characterized the expression profile of circRNAs in skeletal muscle and discussed regulatory functions and mechanism-of-action of specific circRNAs in myogenesis. The future investigation into the roles of circRNAs in both physiological and pathological conditions may provide novel insights in skeletal muscle development and provide new therapeutic strategies for muscular diseases. View Full-Text
Keywords: circular RNA; circRNA; skeletal muscle; myogenesis circular RNA; circRNA; skeletal muscle; myogenesis

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Zhang, P.; Chao, Z.; Zhang, R.; Ding, R.; Wang, Y.; Wu, W.; Han, Q.; Li, C.; Xu, H.; Wang, L.; Xu, Y. Circular RNA Regulation of Myogenesis. Cells 2019, 8, 885.

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