Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-xL
Abstract
:1. Introduction
2. Materials and Methods
2.1. Purification and Culture of Human Skin Mast Cells and Other Skin Cells
2.2. Cell Treatment
2.3. Analysis of Survival
2.4. Staining of Intracellular and Extracellular Proteins
2.5. siRNA Transfection
2.6. RT-quantitative PCR
SCF | Forward | GCGTGGACTATCTGCCGCCG |
Reverse | AGCGCTGCGATCCAGCACAAA | |
IL-33 | Forward | TGTCAACAGCAGTCTACTGTGG |
Reverse | TGGACCCCTGATATACCAAAGG |
2.7. Immunoblotting
2.8. Statistical Analysis
3. Results
3.1. TSLP Counters Apoptosis of Skin MCs upon Growth Factor Withdrawal
3.2. TSLP Triggers Activation of STAT5 and JNK
3.3. MC Maintenance by TSLP Critically Depends on JNK and STAT5
3.4. TSLP up-Regulates Mcl-1 and Bcl-xL
3.5. Survival by TSLP Depends on Mcl-1 and Bcl-xL
3.6. STAT5 Perturbation Leads to Mcl-1 Downregulation, While Interference with JNK Attenuates Bcl-xL Expression
3.7. TSLP Protects Skin MCs Ex Vivo from Cell Death
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Hazzan, T.; Eberle, J.; Worm, M.; Babina, M. Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-xL. Cells 2019, 8, 829. https://doi.org/10.3390/cells8080829
Hazzan T, Eberle J, Worm M, Babina M. Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-xL. Cells. 2019; 8(8):829. https://doi.org/10.3390/cells8080829
Chicago/Turabian StyleHazzan, Tarek, Jürgen Eberle, Margitta Worm, and Magda Babina. 2019. "Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-xL" Cells 8, no. 8: 829. https://doi.org/10.3390/cells8080829