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Article

Genetic Association between Swine Leukocyte antigen Class II Haplotypes and Reproduction Traits in Microminipigs

1
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara 259-1193, Japan
2
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan
3
Faculty of Health and Medical Sciences, UWA Medical School, The University of Western Australia, Crawley WA 6009, Australia
4
Laboratory of Veterinary Internal Medicine, Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoino-oka, Imabari, Ehime 794-8555, Japan
*
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 783; https://doi.org/10.3390/cells8080783
Received: 28 May 2019 / Revised: 16 July 2019 / Accepted: 22 July 2019 / Published: 26 July 2019
(This article belongs to the Special Issue Major Histocompatibility Complex (MHC) in Health and Disease)
The effects of swine leukocyte antigen (SLA) molecules on numerous production and reproduction performance traits have been mainly reported as associations with specific SLA haplotypes that were assigned using serological typing methods. In this study, we intended to clarify the association between SLA class II genes and reproductive traits in a highly inbred population of 187 Microminipigs (MMP), that have eight different types of SLA class II haplotypes. In doing so, we compared the reproductive performances, such as fertility index, gestation period, litter size, and number of stillbirth among SLA class II low resolution haplotypes (Lrs) that were assigned by a polymerase chain reaction-sequence specific primers (PCR-SSP) typing method. Only low resolution haplotypes were used in this study because the eight SLA class II high-resolution haplotypes had been assigned to the 14 parents or the progenitors of the highly inbred MMP herd in a previous publication. The fertility index of dams with Lr-0.13 was significantly lower than that of dams with Lr-0.16, Lr-0.17, Lr-0.18, or Lr-0.37. Dams with Lr-0.23 had significantly smaller litter size at birth than those with Lr-0.17, Lr-0.18, or Lr-0.37. Furthermore, litter size at weaning of dams with Lr-0.23 was also significantly smaller than those dams with Lr-0.16, Lr-0.17, Lr-0.18, or Lr-0.37. The small litter size of dams with Lr-0.23 correlated with the smaller body sizes of these MMPs. These results suggest that SLA class II haplotypes are useful differential genetic markers for further haplotypic and epistatic studies of reproductive traits, selective breeding programs, and improvements in the production and reproduction performances of MMPs. View Full-Text
Keywords: swine leukocyte antigen; reproductive performance; production trait; haplotype; micro-mini-pigs swine leukocyte antigen; reproductive performance; production trait; haplotype; micro-mini-pigs
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MDPI and ACS Style

Ando, A.; Imaeda, N.; Matsubara, T.; Takasu, M.; Miyamoto, A.; Oshima, S.; Nishii, N.; Kametani, Y.; Shiina, T.; Kulski, J.K.; Kitagawa, H. Genetic Association between Swine Leukocyte antigen Class II Haplotypes and Reproduction Traits in Microminipigs. Cells 2019, 8, 783. https://doi.org/10.3390/cells8080783

AMA Style

Ando A, Imaeda N, Matsubara T, Takasu M, Miyamoto A, Oshima S, Nishii N, Kametani Y, Shiina T, Kulski JK, Kitagawa H. Genetic Association between Swine Leukocyte antigen Class II Haplotypes and Reproduction Traits in Microminipigs. Cells. 2019; 8(8):783. https://doi.org/10.3390/cells8080783

Chicago/Turabian Style

Ando, Asako; Imaeda, Noriaki; Matsubara, Tatsuya; Takasu, Masaki; Miyamoto, Asuka; Oshima, Shino; Nishii, Naohito; Kametani, Yoshie; Shiina, Takashi; Kulski, Jerzy K.; Kitagawa, Hitoshi. 2019. "Genetic Association between Swine Leukocyte antigen Class II Haplotypes and Reproduction Traits in Microminipigs" Cells 8, no. 8: 783. https://doi.org/10.3390/cells8080783

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