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NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction

Department of Biomedical Science, Chosun University, Gwangju 61452, Korea
Department of Bioinformatics, Kongju National University, Kongju 38065, Korea
Authors to whom correspondence should be addressed.
Cells 2019, 8(7), 734;
Received: 15 June 2019 / Revised: 15 July 2019 / Accepted: 15 July 2019 / Published: 17 July 2019
(This article belongs to the Special Issue Pathways Contributing to Cartilage and Bone Destruction in Arthritis)
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation, and aging. Mechanical stress along with synovial inflammation promotes the degradation of the extracellular matrix in the cartilage, leading to the breakdown of joint cartilage. The nuclear factor-kappaB (NF-κB) transcription factor has long been recognized as a disease-contributing factor and, thus, has become a therapeutic target for OA. Because NF-κB is a versatile and multi-functional transcription factor involved in various biological processes, a comprehensive understanding of the functions or regulation of NF-κB in the OA pathology will aid in the development of targeted therapeutic strategies to protect the cartilage from OA damage and reduce the risk of potential side-effects. In this review, we discuss the roles of NF-κB in OA chondrocytes and related signaling pathways, including recent findings, to better understand pathological cartilage remodeling and provide potential therapeutic targets that can interfere with NF-κB signaling for OA treatment. View Full-Text
Keywords: NF-κB; osteoarthritis; cartilage degeneration; chondrocyte catabolism; chondrocyte apoptosis; IκBζ NF-κB; osteoarthritis; cartilage degeneration; chondrocyte catabolism; chondrocyte apoptosis; IκBζ
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Choi, M.-C.; Jo, J.; Park, J.; Kang, H.K.; Park, Y. NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction. Cells 2019, 8, 734.

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