Next Article in Journal
Response of the Green Alga Chlamydomonas reinhardtii to the DNA Damaging Agent Zeocin
Next Article in Special Issue
Cartilage and Bone Destruction in Arthritis: Pathogenesis and Treatment Strategy: A Literature Review
Previous Article in Journal
RhoA as a Key Regulator of Innate and Adaptive Immunity
Previous Article in Special Issue
The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments
Open AccessReview

NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction

1
Department of Biomedical Science, Chosun University, Gwangju 61452, Korea
2
Department of Bioinformatics, Kongju National University, Kongju 38065, Korea
*
Authors to whom correspondence should be addressed.
Cells 2019, 8(7), 734; https://doi.org/10.3390/cells8070734
Received: 15 June 2019 / Revised: 15 July 2019 / Accepted: 15 July 2019 / Published: 17 July 2019
(This article belongs to the Special Issue Pathways Contributing to Cartilage and Bone Destruction in Arthritis)
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation, and aging. Mechanical stress along with synovial inflammation promotes the degradation of the extracellular matrix in the cartilage, leading to the breakdown of joint cartilage. The nuclear factor-kappaB (NF-κB) transcription factor has long been recognized as a disease-contributing factor and, thus, has become a therapeutic target for OA. Because NF-κB is a versatile and multi-functional transcription factor involved in various biological processes, a comprehensive understanding of the functions or regulation of NF-κB in the OA pathology will aid in the development of targeted therapeutic strategies to protect the cartilage from OA damage and reduce the risk of potential side-effects. In this review, we discuss the roles of NF-κB in OA chondrocytes and related signaling pathways, including recent findings, to better understand pathological cartilage remodeling and provide potential therapeutic targets that can interfere with NF-κB signaling for OA treatment. View Full-Text
Keywords: NF-κB; osteoarthritis; cartilage degeneration; chondrocyte catabolism; chondrocyte apoptosis; IκBζ NF-κB; osteoarthritis; cartilage degeneration; chondrocyte catabolism; chondrocyte apoptosis; IκBζ
Show Figures

Figure 1

MDPI and ACS Style

Choi, M.-C.; Jo, J.; Park, J.; Kang, H.K.; Park, Y. NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction. Cells 2019, 8, 734.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop